PMID: 9553995Apr 29, 1998Paper

Prolactin response to bromperidol treatment in schizophrenic patients

Pharmacology & Toxicology
N YasuiY Inoue

Abstract

The prolactin response to an antipsychotic drug, bromperidol was studied in 24 schizophrenic in-patients (13 males. 11 females). Eight patients were given 6 mg/day, 8 were given 18 mg/day. Duration of treatment was 3 weeks. Plasma concentrations of bromperidol and reduced bromperidol were measured by high-performance liquid chromatography, and that of prolactin was measured by radioimmunoassay. Bromperidol treatment significantly (P < 0.01) increased plasma concentration of prolactin each week. The mean +/- S.D. of the delta-prolactin (the mean concentration during treatment minus the pretreatment concentration) was 13.3 +/- 12.4 ng/ml. Multiple regression analysis showed that the delta-prolactin concentration was significantly greater in females than in males (P < 0.05) and correlated to plasma concentrations of bromperidol (P < 0.001) and reduced bromperidol (P < 0.0001). These results suggest that the prolactin response to bromperidol treatment depend on plasma concentrations of both bromperidol and reduced bromperidol and gender, and that reduced bromperidol is involved in the pharmacological effects during bromperidol treatment.

References

Jan 1, 1984·European Archives of Psychiatry and Neurological Sciences·P LinkowskiJ Mendlewicz
Jan 1, 1994·International Clinical Psychopharmacology·K OtaniY Fukushima

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Citations

Feb 21, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Norio Yasui-FurukoriKoichi Otani
May 10, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Norio Yasui-FurukoriKoichi Otani
Sep 23, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Tsuyoshi KondoSunao Kaneko
Jun 27, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Norio Yasui-FurukoriSunao Kaneko
Jan 11, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chikako OhtaSunao Kaneko
Jan 29, 2017·Expert Opinion on Pharmacotherapy·Bettina LangeJ Malte Bumb
Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Norio Yasui-FurukoriTomonori Tateishi
Nov 26, 2003·Therapeutic Drug Monitoring·Norio Yasui-FurukoriTomonori Tateishi

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