Prolactin response to d-fenfluramine in postmenopausal women on and off ERT: comparison with young women

Psychoneuroendocrinology
T A M J van AmelsvoortD G Murphy

Abstract

Estrogen is thought to have an impact on both psychological well being and cognitive function. The biological basis to this is not fully understood, but may involve estrogen's interactions with central serotonergic (5-HT) systems. Therefore, we studied the effect of long-term estrogen hormone replacement therapy (ERT) on central 5-HT tone in healthy postmenopausal women and made comparisons with young women. Prolactin (PRL) responses to the specific 5-HT releasing and re-uptake inhibiting agent, d-fenfluramine, were measured in three groups of healthy women: 11 young, 11 postmenopausal on long-term ERT, and 11 postmenopausal ERT naïve. PRL responses were significantly decreased in ERT naïve women compared to young healthy women. In contrast, PRL responses were not different between estrogen-treated and young women. Overall, there was a significant relationship between older age and lower PRL responsivity. These results suggest that central 5-HT tone is reduced in healthy postmenopausal women who are ERT naïve, but not in postmenopausal women who have received prolonged estrogen treatment. Estrogen may modulate age-related changes in 5-HT tone. This may partly explain why estrogen can decrease vulnerability to mood disorders and...Continue Reading

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Citations

Jan 25, 2003·Experimental Gerontology·Ray NorburyDeclan G Murphy
Jul 11, 2001·Trends in Endocrinology and Metabolism : TEM·T van AmelsvoortD Murphy
Feb 17, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julie DumasPaul Newhouse
Jun 9, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Zenab AminC Neill Epperson
Feb 22, 2005·Lancet Neurology·Michael C CraigDeclan G M Murphy
Nov 26, 2008·Best Practice & Research. Clinical Obstetrics & Gynaecology·Michael C Craig, Declan G M Murphy
Mar 3, 2004·Annals of the New York Academy of Sciences·William J CutterDeclan G Murphy
Sep 16, 2010·Annals of the New York Academy of Sciences·Michael C Craig, D G M Murphy
Jul 9, 2002·Best Practice & Research. Clinical Obstetrics & Gynaecology·Jacqueline ComptonDeclan Murphy
Dec 23, 2006·Journal of Neuroendocrinology·M C Craig, D G Murphy
Oct 27, 2007·Climacteric : the Journal of the International Menopause Society·M C Craig, D G Murphy
Mar 22, 2002·Frontiers in Neuroendocrinology·Cynthia L BetheaJohn M Streicher
May 12, 2005·Behavioral and Cognitive Neuroscience Reviews·Zenab AminC Neill Epperson
Jul 22, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill M GoldsteinRobert J Handa

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