PMID: 2506942Jan 1, 1989Paper

Prolactin response to dopamine and valproate administration in breast cancer patients

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
G B StalldeckerI Vegh

Abstract

There is only indirect evidence available at present to suggest the role of prolactin (PRL) in either the promotion or progression of human breast cancer. In order to determine if dopaminergic and GABAergic regulation of PRL are similar in breast cancer patients, we studied 2 groups of premenopausal women with no evident endocrine alteration: 1) control subjects (C); and 2) breast cancer patients (CA). Basal PRL levels were measured and their response to dopamine (DA) infusion (0.004 micrograms/kg/min) and valproate administration (400 mg/p.o.). The mean of percentage inhibition by DA in C (n = 6) was significantly higher than in CA (n = 11) at 180 min; P less than 0.025. On the other hand, group C (n = 8) responded to valproate with maximal inhibition at 180 min; in the CA group (n = 8) no inhibition was observed; P less than 0.0025.

References

Feb 1, 1976·Molecular and Cellular Endocrinology·J A Rillema, L D Anderson
Oct 1, 1977·Clinical Endocrinology·G A Smythe
Mar 16, 1974·Lancet·H G KwaF J Cleton
May 11, 1974·Lancet·I MittraA S McNeilly
Jul 15, 1973·Harefuah·H Horn, Y Horn
Aug 30, 1982·Life Sciences·G RacagniE E Muller
Mar 1, 1982·The Journal of Clinical Endocrinology and Metabolism·G B MelisP Fioretti
Apr 1, 1983·The Journal of Clinical Endocrinology and Metabolism·W B MalarkeyG Milo
Jun 1, 1983·The Journal of Clinical Endocrinology and Metabolism·C B WebbL A Frohman
Apr 1, 1965·The Journal of Endocrinology·J B BROWN, J A STRONG

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Citations

Nov 30, 2007·Journal of Carcinogenesis·Irene Vegh, Rafael Enríquez de Salamanca

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