PMID: 36978Jun 1, 1979

Prolactin-secreting adenoma as part of the multiple endocrine neoplasia--type I (MEN-I) syndrome

J H LevineJ M Powers


Two patients presented with the galactorrhea-amenorrhea syndrome. One patient had previously had parathyroid hyperplasia and the other an insulinoma. Preoperative evaluation of each patient revealed hyperprolactinemia and radiological evidence of an abnormal sella turcica. Pituitary adenomas were identified and removed at surgery. Immunostaining techniques confirmed the presence of prolactin-containing cells in both tumors. We propose that prolactin-secreting tumors be considered as part of the MEN-I syndrome, and that patients presenting with the galactorrhea-amenorrhea syndrome be screened and followed sequentially for evidence of other endocrine neoplasia.


May 1, 1976·The Journal of Clinical Endocrinology and Metabolism·B CorenblumC Ezrin
Jan 29, 1976·The New England Journal of Medicine·R M BoyarL Hellman
May 1, 1976·Clinical Endocrinology·S NaderG F Joplin
Mar 15, 1975·British Medical Journal·D F ChildT R Fraser
Sep 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·T E MasonR B Dreskin
Mar 1, 1954·The American Journal of Medicine·P WERMER
Jul 1, 1964·Medicine·H S BALLARDR J HARTSOCK
Mar 1, 1962·The Journal of Clinical Endocrinology and Metabolism·J W RAKERW S GRAF

Related Concepts

Adenoma, Trabecular
Parathyroid Diseases
PRL gene
Multiple Endocrine Neoplasia Type 1
Pituitary Neoplasms
Structure of Pituitary Fossa

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