Aug 1, 1976

Prolactin secretion by metoclopramide in man

The Journal of Clinical Endocrinology and Metabolism
S J JuddG Smythe


Six men and nine women were given intravenous injections of 2.5 mg of metoclopramide to assess its potential as a stimulus to prolactin release. Following the administration of metoclopramide, there was prompt increase in serum prolactin to a peak response of 38.2 +/- 3.9 ng/ml in men and 103 +/- 10.2 ng/ml in women. The prolactin response to metoclopramide in men was compared with the response to 400 mug of TRH in 10 men. The peak response after TRH was 22.4 +/- 2.2 ng/ml, which was significantly less than that observed after metoclopramide. Pretreatment with 500 mg of L-dopa suppressed the prolactin response to metoclopramide in 6 men to a mean response of 16.3 +/- 4.3 ng/ml. We have concluded that metoclopramide is a safe, reliable, and potent stimulus of prolactin secretion and exerts this effect by blocking dopamine receptors in the hypothalamus and decreasing prolactin inhibiting factor. It is free of side effects and is a useful alternative to chlorpromazine.

  • References
  • Citations41


  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Intravenous Injections
Organum Vasculosum Laminae Terminalis
Prolactin Release-Inhibiting Hormone
PRL gene
Pituitary Gland, Anterior
Drug Interactions

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

British Medical Journal
A S McNeillyG M Besser
The Journal of Clinical Endocrinology and Metabolism
J R SowersN Meyer
Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses
Sandra A Cericola
© 2020 Meta ULC. All rights reserved