PMID: 16526181Mar 11, 2006Paper

Prolactin secretion disturbances in schizophrenic patients treated with 2nd generation antipsychotics--risperidone and olanzapine

Psychiatria polska
Anna Wyszogrodzka-KucharskaJolanta Rabe-Jabłońska

Abstract

Hyperprolactinemia is an elevation ofprolactin level above the norm in two separate samples. Its prevalence is 0.4%. Hyperprolactinemia could be a side effect oftreatment of schizophrenia with conventional and some of the second generation antipsychotics. To compare the prevalence of hyperprolactinemia and its clinical symptoms in three groups: (1) patients with schizophrenia treated with risperidone, (2) those treated with olanzapine and (3) the control group. Participants in the study were 60 schizophrenic patients: 26 treated with risperidone, 34 with olanzapine and 38 healthy, non-medicated volunteers. In all subjects a fasting morning blood sample was obtained and analyzed for serum prolactin levels. Investigators did not establish any statistically significant difference in the prevalence of hyperprolactinemia diagnosed with laboratory tests in patients treated with different atypical neuroleptics. Hyperprolactinemia was established in 92.3% patients treated with risperidone and in 76.5% patients treated with olanzapine and in 2.6% subjects of the control group. Clinical symptoms of hyperprolactinemia were established only in a part of the subjects with hiperprolactinemia diagnosed with laboratory tests.

Related Concepts

Related Feeds

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here