Prolactin secretory rhythm in women: immediate and long-term alterations after sexual contact

Human Reproduction
Tillmann H C KrugerMarcel Egli

Abstract

Prolactin (PRL) is one of the most versatile hormones in the mammalian body, affecting reproductive, sexual and other functions. In rats, mating or vaginocervical stimulation activates a characteristic PRL secretory pattern for several days, which is essential for successful reproduction. Although the underlying mechanisms appear to be different, PRL is also crucial for human fertility. We have detected a PRL increase in women induced by sexual intercourse. Extending these findings, the current study aimed at analyzing the PRL secretory rhythm after sexual contact, in order to elucidate whether human females also show long-term alterations of the PRL secretory pattern. In a pilot study, serial blood samples were taken from women (n= 7) in mid-cycle to assess changes in PRL secretory rhythm induced by sexual intercourse, during a period of 32 h. Compared with control condition, sexual intercourse with orgasm induced not only the well-established immediate PRL increase of ~300% but also an additional PRL elevation around noon of the next day (P< 0.05). These fluctuations were measured on top of the regular circadian rhythm of PRL, manifested as a surge early in the morning. We are able to demonstrate a long-term change in the PRL...Continue Reading

References

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Aug 25, 2010·Reproduction : the Official Journal of the Society for the Study of Fertility·Marcel EgliTillmann H C Kruger

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Citations

May 7, 2014·Schizophrenia Research and Treatment·Ravi Philip Rajkumar
Mar 1, 2013·Clinical Endocrinology·Macarena AlpañésHéctor F Escobar-Morreale
Jun 24, 2014·Hormones and Behavior·Ankita PrasadEnrique F Schisterman
May 11, 2018·American Journal of Therapeutics·Robert Krysiak, Bogusław Okopień

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