Prolactin synthesis by lymphocytes from patients with systemic sclerosis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Joanna Czuwara-LadykowskaLidia Rudnicka

Abstract

Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of the skin and internal organs. It has been demonstrated that serum prolactin levels are increased in patients with various connective tissue diseases. The aim of this study was to investigate the possible source of excessive prolactin synthesis in SSc and its effects on immune cells. The study group consisted of 52 patients with diffuse SSc (44 women and eight men) and 52 age and sex matched healthy controls. The methods used were: ELISA and indirect immunofluorescence. Our results show significantly elevated level of prolactin in male and female patients with SSc and increased prolactin production by SSc lymphocytes as compared to healthy donors X lymphocytes (25.4+/-11.0 vs. 13.4+/-5.0 absorbance units). Patients X and healthy controls X lymphocytes, showed equal presence of prolactin receptors. Soluble interleukin 2 receptor (CD25) concentration, was significantly higher in supernatants of prolactin stimulated lymphocytes, as compared to non-stimulated lymphocytes. We conclude that lymphocytes might contribute to elevated prolactin levels in patients with SSc and that these cells themselves may be sensitive to prolactin stimulation. Therefore, a ph...Continue Reading

References

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Citations

Dec 22, 2009·Rheumatology International·Markéta FojtíkováMarie Cerná
Nov 17, 2009·Clinical Reviews in Allergy & Immunology·Luis J JaraCarmen Navarro
Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Oct 16, 2013·Clinical Reviews in Allergy & Immunology·Fabio D'AmicoMaria Clorinda Mazzarino
Mar 25, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·M GönülS Külcü Cakmak
Dec 14, 2011·Autoimmunity Reviews·Shahar ShellyHedi Orbach
Nov 1, 2006·Reumatología clinica·Olga Lidia Vera-Lastra, Luis J Jara
Dec 27, 2008·The Journal of Investigative Dermatology·Kerstin FoitzikRalf Paus
Sep 15, 2007·Autoimmunity Reviews·Hedi Orbach, Yehuda Shoenfeld

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