Prolactinoma-associated headache and dopamine agonist treatment

Cephalalgia : an International Journal of Headache
Mia-Maiken KallestrupJens Ol Jørgensen

Abstract

The aim of this article is to investigate the phenotype and etiology of prolactinoma-associated headache as well as present and discuss the plausible pain-relieving effect of dopamine agonist treatment. In this case-based audit we included 11 patients with prolactinomas and one patient with idiopathic hyperprolactinemia presenting with headache that subsequently improved or resolved after dopamine agonist treatment. A significant ipsilateral location of tumor mass and reported headache symptoms was observed (p = 0.018). After dopamine agonist treatment seven out of 12 patients became pain free within 2.5 months; after one year of treatment 11 out of 12 reported headache improvement or resolution. Average tumor volume reduction after treatment was 47 ± 22% during 9.5 ± 8.4 months of follow-up. There was no significant association between headache relief and tumor shrinkage (p = 0.43) or normalization of serum prolactin (p = 1.00), respectively. 1) The significant association between lateralization of tumor and headache suggests a mechanical origin of the headache, 2) headache responded to dopamine agonist treatment in most patients, and 3) our observations encourage future prospective controlled trials to investigate the role of...Continue Reading

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Citations

Mar 13, 2016·The Journal of Headache and Pain·Annelien De PueKoen Paemeleire
May 6, 2016·Frontiers in Immunology·Andrea I LoewendorfMike Harrington
Jun 16, 2018·Current Pain and Headache Reports·Himanshu Suri, Carrie Dougherty
Jun 21, 2015·Current Pain and Headache Reports·Ilse F de CooJoost Haan
Feb 20, 2020·Arquivos de neuro-psiquiatria·Miriam da Costa OliveiraJúlia Fernanda Semmelmann Pereira-Lima
Dec 1, 2018·The Journal of Headache and Pain·Zoë DelaruelleUNKNOWN European Headache Federation School of Advanced Studies (EHF-SAS)
Mar 23, 2019·Cephalalgia : an International Journal of Headache·Yixin ZhangJiying Zhou
Oct 26, 2018·Frontiers in Integrative Neuroscience·Gregory DussorArmen N Akopian
Jan 23, 2020·Arquivos de neuro-psiquiatria·Miriam da Costa OliveiraJúlia Fernanda Semmelmann Pereira-Lima
Jul 6, 2020·Trends in Neurosciences·Yanxia ChenFrank Porreca

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Methods Mentioned

BETA
sandwich immunometric assay

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