Prolactinoma management: predictors of remission and recurrence after dopamine agonists withdrawal

Pituitary
Margarida TeixeiraDavide Carvalho

Abstract

Prolactinomas are the most common functional pituitary tumour. Dopamine agonists (DA) are its principal treatment. The criteria that should guide therapy withdrawal and the factors that influence disease remission or relapse are not yet fully established. Our purpose is to evaluate the proportion of patients who attempted DA withdrawal, and to identify the factors that influence clinicians to try it. In addition, we aim to study the factors that are involved in prolactinoma remission/relapse after therapy withdrawal. We retrospectively evaluated 142 patients with prolactinoma diagnosis who had been treated exclusively with DA. Firstly, the patients were divided in two groups, according to whether DA withdrawal had been attempted, or not, and the factors that might predict clinicians' decision to discontinue the therapy were then analysed. Secondly, patients who attempted withdrawal were further divided into two subgroups, based on their remission or relapse status and predictors of remission were evaluated. DA withdrawal was attempted in 35.2% of our patients. Females, subjects with lower initial serum prolactin (PRL) levels, those with microadenomas and those with longer treatment duration all had a higher probability of seein...Continue Reading

References

Jul 1, 1987·Fertility and Sterility·D A SisamL R Sheeler
Jan 1, 1984·Annals of Internal Medicine·M C KoppelmanD L Loriaux
Feb 1, 1984·The Journal of Clinical Endocrinology and Metabolism·M BassettiG Giannattasio
Jun 1, 1984·The Journal of Clinical Endocrinology and Metabolism·A M Landolt, V Osterwalder
Dec 1, 1982·The Journal of Clinical Endocrinology and Metabolism·G T TindallM O Thorner
Sep 1, 1996·Clinical Endocrinology·W J JeffcoateJ Lambourne
Jul 1, 1997·The Journal of Clinical Endocrinology and Metabolism·E DelgrangeJ Tourniaire
Mar 16, 2001·Expert Opinion on Pharmacotherapy·A ColaoL Annunziato
Aug 6, 2002·The Journal of Clinical Endocrinology and Metabolism·Vanessa Q PassosMarcello D Bronstein
Mar 4, 2003·European Journal of Endocrinology·Annamaria ColaoGaetano Lombardi
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Aug 5, 2006·Clinical Endocrinology·Felipe F CasanuevaAndrea Giustina
Jun 19, 2007·Clinical Endocrinology·Annamaria ColaoGaetano Lombardi
Apr 2, 2009·The Journal of Clinical Endocrinology and Metabolism·J KharlipG S Wand
Nov 3, 2009·The Journal of Clinical Endocrinology and Metabolism·Olaf M DekkersAlberto M Pereira
Feb 8, 2011·The Journal of Clinical Endocrinology and Metabolism·Shlomo MelmedUNKNOWN Endocrine Society
Sep 25, 2014·Handbook of Clinical Neurology·Johannes A Romijn

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Citations

Sep 27, 2019·Pituitary·Pedro SouteiroDavide Carvalho
Apr 20, 2019·Hormones & Cancer·Rita IndirliMaura Arosio
Oct 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Kyungwon KimCheol Ryong Ku
Jul 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Philippe Chanson, Dominique Maiter
Jul 16, 2021·Journal of the Chinese Medical Association : JCMA·Tse-Yu ChenWen-Yu Cheng

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