Prolactinomas in children under 14. Clinical presentation and long-term follow-up

Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery
Yang LiuRenzhi Wang

Abstract

Pediatric prolactinomas are rare, especially in children under 14 years of age. In this study, we evaluated the clinical presentation and microsurgical outcome of prolactinomas in prepubertal children. Nine patients with prolactinomas who had undergone surgical removal of the tumor before the age of 14 years were included in this retrospective study. Data on their clinical presentation, medications, physical and laboratory evaluations, radiological findings, and long-time follow-up were obtained from their medical records. The main presenting symptom in the four female patients was galactorrhea (n = 4, 100%), whereas the five male patients most commonly presented with headache (n = 4, 80%) and growth retardation (n = 3, 60%). Six (66.6%) of the patients who had undergone transsphenoidal surgery were medication-free postoperatively. In three (33.3%) patients with giant adenomas, complete resection of the tumor was not achieved. One (11.1%) patient received radiotherapy after failed surgical and medical treatment. Postoperatively, electrolyte disturbances occurred in five (55.6%) patients, diabetes insipidus in two (22.2%), and thyroid dysfunction in two (22.2%). These complications resolved spontaneously. During follow-up, growt...Continue Reading

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Citations

Feb 24, 2017·The Journal of Craniofacial Surgery·Wei JiaoTing Lei
Nov 28, 2017·Endocrine·Deirdre Cocks EschlerEliza B Geer
Jul 20, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Corinna Melanie BrichtaNatascha van der Werf-Grohmann
Nov 7, 2016·Journal of Pediatric Endocrinology & Metabolism : JPEM·James FelkerAnna Janss
Dec 14, 2018·Frontiers in Endocrinology·Maria de Fátima de Magalhães GonzagaLuiz Augusto Casulari
Oct 24, 2019·Pituitary·M Beatriz S Lopes
Mar 19, 2021·Journal of Paediatrics and Child Health·Rafaela E Linhares, Margaret Zacharin

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