Prolactin's role in the pathogenesis of the antiphospholipid syndrome

Lupus
S PraprotnikYehuda Shoenfeld

Abstract

Increased levels of serum prolactin have been reported in patients with various autoimmune diseases and have been associated with lupus disease activity. Currently, there is a lack of data regarding hyperprolactinaemia in patients with the antiphospholipid syndrome. Hence, this study was carried out in order to evaluate the prevalence and clinical significance of hyperprolactinaemia in antiphospholipid syndrome. A total of 172 European patients with antiphospholipid syndrome and 100 geographically and sex-matched healthy controls were included in the study; none had obvious causes of hyperprolactinaemia. All patients underwent clinical assessment for disease manifestations, in addition to laboratory assessment for serum prolactin, antiphospholipid antibodies and some other biomarkers of autoimmune diseases. The tests were performed utilizing the LIAISON® Analyzer (DiaSorin, Sallugia Italy). Hyperprolactinaemia was detected in 21/172 patients with antiphospholipid syndrome and 0/100 controls (p < 0.001). This significant difference was present in both genders and was obvious even after subgrouping the patients into primary and secondary antiphospholipid syndrome. When clinical features were compared, hyperprolactinaemia was asso...Continue Reading

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Citations

Feb 3, 2011·Clinical Reviews in Allergy & Immunology·Hedi OrbachYehuda Shoenfeld
Mar 2, 2011·Cellular & Molecular Immunology·Nancy Agmon-LevinYehuda Shoenfeld
Nov 6, 2013·Nature Reviews. Endocrinology·Aritro SenNorbert Gleicher
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Feb 28, 2018·Frontiers in Immunology·Vânia Vieira BorbaYehuda Shoenfeld
Oct 31, 2017·American Journal of Reproductive Immunology : AJRI·Vânia Vieira BorbaYehuda Shoenfeld
Jan 8, 2019·American Journal of Reproductive Immunology : AJRI·Amanpreet Kaur KalsiJai Bhagwan Sharma
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