PMID: 9179267May 1, 1997Paper

Proliferating cell nuclear antigen expression in the gallbladder with pancreaticobiliary maljunction

Journal of Surgical Oncology
H IsozakiH Mabuchi

Abstract

To clarify the histogenesis of cancer of the gallbladder of the patients with pancreaticobiliary maljunction (PBMJ), the proliferating cell activity of the epithelium of gallbladder was examined. A total of 21 patients with pancreaticobiliary maljunction [8 with gallbladder cancer (MCA group) and 13 without cancer (M group)] were studied using immunohistochemical staining with a monoclonal antibody to the proliferating cell nuclear antigen (PCNA). The 23 gallbladder cancer patients without PBMJ (CA group) and 10 patients with normal gallbladders (N group) were also examined as controls. The PCNA-positive rates of non-cancerous epithelium of the gallbladder in patients with PBMJ (14.2% in MCA group and 11.6% in M group) were significantly higher than those without PBMJ (3.9% in CA group and 1.5% in N group). The high proliferating cell activity of epithelium of the gallbladder may be an explantation for the high incidence of gallbladder cancer in patients with pancreaticobiliary maljunction.

References

Sep 1, 1991·The Keio Journal of Medicine·T FunabikiM Ochiai
Dec 1, 1981·The Journal of Experimental Medicine·Y TakasakiE M Tan

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Citations

May 1, 2008·Expert Opinion on Medical Diagnostics·Priya RupeshShukla Vijay Kumar
Dec 8, 2011·Hepatobiliary & Pancreatic Diseases International : HBPD INT·Yi-Lei DengXian-Ze Xiong
May 27, 2008·Langenbeck's Archives of Surgery·Takahiko FunabikiShin Ishihara

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