Proliferating immature Schwann cells contribute to nerve regeneration after ischemic peripheral nerve injury

Journal of Neuropathology and Experimental Neurology
Masaki KobayashiHidehiro Mizusawa

Abstract

Schwann cells exhibit a high degree of plasticity in adult peripheral nerves after mechanical injury; they have, therefore, been implicated in promoting nerve regeneration. However, Schwann cell behavior after ischemic injury has not yet been elucidated. To determine how Schwann cell plasticity may contribute to recovery from ischemic neuropathy, we used a rat model in which ischemia was induced in the tibial nerve by a 5-hour occlusion of the supplying arteries. Proliferation of immature Schwann cells that emerged in the injured nerve was evaluated by double immunostaining for the p75 neurotrophin receptor and proliferating cell nuclear antigen. The number of proliferating cell nuclear antigen/p75 neurotrophin receptor double-positive cells increased significantly in 1 to 2 weeks after ischemia and subsequently decreased by 4 weeks. During this time, the postmitotic Schwann cells differentiated into mature cells, as demonstrated with bromodeoxyuridine incorporation, which facilitated axon guidance and subsequent axon remyelination. These results suggest the emergence and proliferation of immature Schwann cells that contribute to nerve regeneration after ischemic injury. The manipulation of this population of proliferating imma...Continue Reading

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Citations

Jul 13, 2013·International Journal of Biological Sciences·Junxiong MaLiangbi Xiang
Sep 23, 2014·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rick Meeker, Kimberly Williams
Sep 17, 2013·Glia·María Alejandra Lopez-VerrilliFelipe A Court
Apr 23, 2014·Journal of Neuroscience Research·Beier LuoMing Li
Jul 16, 2019·The Journal of International Medical Research·Tengfei FuJian Zhang
Apr 1, 2021·Journal of Biomedical Nanotechnology·Kai YeJiabo Hu
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Lynn NazarethJenny Ekberg

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