Proliferating mesodermal cells in murine embryos exhibiting macrophage and lymphendothelial characteristics.

BMC Developmental Biology
Kerstin ButtlerJörg Wilting

Abstract

The data on the embryonic origin of lymphatic endothelial cells (LECs) from either deep embryonic veins or mesenchymal (or circulating) lymphangioblasts presently available remain inconsistent. In various vertebrates, markers for LECs are first expressed in specific segments of embryonic veins arguing for a venous origin of lymph vessels. Very recently, studies on the mouse have strongly supported this view. However, in the chick, we have observed a dual origin of LECs from veins and from mesodermal lymphangioblasts. Additionally, in murine embryos we have detected mesenchymal cells that co-express LEC markers and the pan-leukocyte marker CD45. Here, we have characterized the mesoderm of murine embryos with LEC markers Prox1, Lyve-1 and LA102 in combination with macrophage markers CD11b and F4/80. We observed cells co-expressing both types of markers (e.g. Prox1 - Lyve-1 - F4/80 triple-positive) located in the mesoderm, immediately adjacent to, and within lymph vessels. Our proliferation studies with Ki-67 antibodies showed high proliferative capacities of both the Lyve-1-positive LECs of lymph sacs/lymphatic sprouts and the Lyve-1-positive mesenchymal cells. Our data argue for a dual origin of LECs in the mouse, although the p...Continue Reading

References

Jan 1, 1986·Virchows Archiv. A, Pathological Anatomy and Histopathology·M Dictor
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·K A HainesG J Thorbecke
Oct 1, 1996·In Vitro Cellular & Developmental Biology. Animal·N C TalbotV G Pursel
Feb 26, 1999·The Journal of Cell Biology·S BanerjiD G Jackson
Feb 1, 2000·Journal of Cellular Physiology·T Scholzen, J Gerdes
Jun 3, 2000·Nature Genetics·M J KarkkainenD N Finegold
Jun 17, 2000·American Journal of Human Genetics·A IrrthumM Vikkula
Dec 13, 2000·The Journal of Biological Chemistry·A ObergfellS J Shattil
Jan 11, 2001·Histochemistry and Cell Biology·M PapoutsiJ Wilting
Feb 15, 2001·Nature Medicine·S A StackerM G Achen
Mar 30, 2001·The Journal of Biological Chemistry·R PrevoD G Jackson
Oct 12, 2001·Microscopy Research and Technique·M H WitteC L Witte
Oct 26, 2001·Mechanisms of Development·T I HeinoC Roos
Apr 3, 2002·The EMBO Journal·Jeffrey T WigleGuillermo Oliver
Apr 24, 2002·Immunity·Attila MócsaiClifford A Lowell
Jun 13, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jörg WiltingJochen Rössler
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki
Mar 21, 2003·Virchows Archiv : an International Journal of Pathology·Silvana GeleffGeorg Oberhuber
Apr 15, 2003·Nature Medicine·Patrizia BarozziGiuseppe Torelli
Aug 20, 2003·Cellular Microbiology·Marie Meister, Marie Lagueux
Aug 28, 2003·Cell and Tissue Research·Michael JeltschJörg Wilting
Oct 29, 2003·The Journal of Cell Biology·Michael S Pepper, Mihaela Skobe
Dec 14, 2004·Genesis : the Journal of Genetics and Development·Dmitry Popichenko, Achim Paululat
Mar 17, 2005·Lymphatic Research and Biology·Lauren Cheung, Stanley G Rockson
Sep 3, 2005·The Journal of Clinical Investigation·Kazuichi MaruyamaJ Wayne Streilein
Oct 28, 2005·Proceedings of the National Academy of Sciences of the United States of America·Li-Ru YouMing-Jer Tsai
Nov 29, 2005·Experimental Cell Research·Annelii NyPeter Carmeliet
Dec 16, 2005·Nature·Kari AlitaloTatiana V Petrova
Dec 27, 2005·Current Medicinal Chemistry·J WiltingM Papoutsi
Feb 7, 2006·Developmental Biology·Jörg WiltingMaria Papoutsi

❮ Previous
Next ❯

Citations

Oct 24, 2008·Histochemistry and Cell Biology·Hélène Maby-El Hajjami, Tatiana V Petrova
Jun 8, 2012·Cold Spring Harbor Perspectives in Medicine·Adrian Zumsteg, Gerhard Christofori
Mar 13, 2010·Development·Xianghu QuScott Baldwin
Mar 5, 2014·The Journal of Clinical Investigation·Nancy H Ruddle
May 22, 2010·Cellular and Molecular Life Sciences : CMLS·Boris StrilićEckhard Lammert
Nov 23, 2010·La Presse médicale·Isabelle Quéré
Sep 15, 2009·Birth Defects Research. Part C, Embryo Today : Reviews·Matthew G ButlerBrant M Weinstein
Jul 4, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A FlahtA Ratajska
Apr 5, 2014·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Aleksandra Flaht-ZabostAnna Ratajska
Jan 26, 2013·Progress in Retinal and Eye Research·Felix BockClaus Cursiefen
Feb 12, 2013·Experimental Cell Research·Ines Martinez-Corral, Taija Makinen
Feb 25, 2010·Cell·Tuomas Tammela, Kari Alitalo
Sep 4, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Françoise Bruyère, Agnès Noël
Oct 16, 2009·The Journal of Pharmacology and Experimental Therapeutics·Xiao-dong PengYu-quan Wei
Jan 1, 2014·Vascular Cell·Matthias S RoostSusana M Chuva de Sousa Lopes
Jul 1, 2020·BMC Pregnancy and Childbirth·Jürgen BeckerJörg Wilting
Aug 3, 2011·Journal of Cell Science·Nikolai DickeKlaus Willecke

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Related Papers

Developmental Biology
Jörg WiltingMaria Papoutsi
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Kerstin ButtlerJörg Wilting
Developmental Dynamics : an Official Publication of the American Association of Anatomists
Emma J GordonNatasha Harvey
© 2022 Meta ULC. All rights reserved