Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells

Molecular Biology of the Cell
L M NeriAlberto M Martelli

Abstract

Previous results have shown that the human promyelocytic leukemia HL-60 cell line responds to either proliferating or differentiating stimuli. When these cells are induced to proliferate, protein kinase C (PKC)-beta II migrates toward the nucleus, whereas when they are exposed to differentiating agents, there is a nuclear translocation of the alpha isoform of PKC. As a step toward the elucidation of the early intranuclear events that regulate the proliferation or the differentiation process, we show that in the HL-60 cells, a proliferating stimulus (i.e., insulin-like growth factor-I [IGF-I]) increased nuclear diacylglycerol (DAG) production derived from phosphatidylinositol (4,5) bisphosphate, as indicated by the inhibition exerted by 1-O-octadeyl-2-O-methyl-sn-glycero-3-phosphocholine and U-73122 (1-[6((17 beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl]-1H-pyrrole-2,5-dione), which are pharmacological inhibitors of phosphoinositide-specific phospholipase C. In contrast, when HL-60 cells were induced to differentiate along the granulocytic lineage by dimethyl sulfoxide, we observed a rise in the nuclear DAG mass, which was sensitive to either neomycin or propranolol, two compounds with inhibitory effect on phospholipase...Continue Reading

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Citations

Jun 15, 2007·Pflügers Archiv : European journal of physiology·Dora Visnjic, Hrvoje Banfic
Jan 20, 2004·Pharmacology & Therapeutics·Alberto M MartelliLucio Cocco
Nov 14, 2002·Molecular Biology of the Cell·Zachary FreybergDennis Shields
May 2, 2006·Molecular and Cellular Biology·Nader OmidvarRichard L Darley
Dec 4, 2004·Journal of Cellular Biochemistry·Eraldo L BatistaThomas E Van Dyke
May 3, 2005·Biochimica Et Biophysica Acta·Vesna Lukinovic-SkudarDora Visnjic
Sep 1, 2004·Cellular Signalling·Giovanna TabelliniAlberto Maria Martelli
May 30, 2006·Biochimica Et Biophysica Acta·Kaoru GotoHisatake Kondo
Apr 21, 2006·Biochimica Et Biophysica Acta·Lucio CoccoFrancesco A Manzoli
Apr 1, 2006·Biochimica Et Biophysica Acta·Alberto M MartelliFrancesco Antonio Manzoli
Mar 3, 2015·Biochimica Et Biophysica Acta·Roberta FiumeNullin Divecha
Sep 19, 2014·Biochemical Society Transactions·Alessandro PoliMatilde Y Follo
Oct 23, 2009·Trends in Cell Biology·Christy A BarlowRichard A Anderson
Jul 19, 2006·Advances in Enzyme Regulation·Lucio CoccoFrancesco Antonio Manzoli
Nov 25, 2014·Breast Cancer Research and Treatment·K SubediC J Field
Jan 18, 2003·Journal of Cellular Biochemistry·Alberto M MartelliL M Neri
Mar 19, 2005·Journal of Leukocyte Biology·Mauricio Di Fulvio, Julian Gomez-Cambronero
Aug 2, 2014·Journal of Leukocyte Biology·Julian Gomez-Cambronero, Samuel Kantonen
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Jan 7, 2020·Cell Cycle·Mo ChenRichard A Anderson
Jun 30, 2019·International Journal of Molecular Sciences·R FiumeN Divecha
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristen L HoekWasif N Khan

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