PMID: 6986181Jan 1, 1980Paper

Proliferation activity and bacteriostatic potential of human blood monocytes, macrophages in pleural effusions, ascites, and of alveolar macrophages

Blut
G MeuretH J Senn

Abstract

Human blood monocytes, macrophages from pleural effusions, ascites, and alveolar macrophages obtained by bronchopulmonary lavage were investigated. The proliferative activity of these cells was determined by the 3H-thymidine labeling index in vitro (3H-TDR L.I.). The bacteriostatic capacity was measured by the potential of the cells to block DNA-synthesis of proliferating Escherichia coli after phagocytosis. In most cases 3H-TDR L.I. of blood monocytes, macrophages from pleural effusions and ascites was less than 1%. However, macrophages of some patients with neoplastic diseases exhibited 3H-TDR L.I. between 4.0--9.6%. This probably reflected the action of factors, possibly lymphokines, which stimulated macrophage proliferation. In contrast, alveolar macrophages seemed to have almost totally lost their proliferative potential. The bacteriostatic capacity of blood monocytes proved to be significantly lower than that of macrophages. This demonstrates the functional immaturity of blood monocytes. In all type of macrophages investigated the bacteriostatic power was very high. No differences could be detected either between macrophages of different sources or between macrophages of benign, inflammatory, or malignant diseases.

References

Jan 1, 1978·Annals of Internal Medicine·M J ClineD W Golde
Jan 1, 1975·Acta Haematologica·G MeuretH van Lessen
Aug 1, 1976·The Journal of Clinical Investigation·J A JuersW W Cook
Nov 1, 1975·The Journal of Experimental Medicine·T J GoudR van Furth
Jan 1, 1973·International Review of Cytology·S Gordon, Z A Cohn
Apr 18, 1974·The New England Journal of Medicine·D W GoldeM J Cline
Jan 1, 1973·The Journal of Pathology·G P Velo, W G Spector
Feb 8, 1974·Nature·D W GoldeT N Finley
Jul 1, 1965·The Journal of Pathology and Bacteriology·W G SpectorD A Willoughby

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Citations

Nov 1, 1993·Experimental Lung Research·M H BaumannC Strange
Nov 1, 1989·Immunobiology·U KubickaA Orkiszewska
Oct 21, 2006·Journal of Leukocyte Biology·Andree SchmidtVeronika Grau
Jun 1, 1987·Environmental Health Perspectives·S Kitamura
Apr 1, 1984·Environmental Health Perspectives·D E Gardner
Oct 1, 1984·Australian and New Zealand Journal of Medicine·G McLennan, N DeYoung
Jun 15, 1985·British Medical Journal·R M Jones
Apr 1, 1986·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·L Athlin, L Domellöf

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