PMID: 12208106Sep 5, 2002Paper

Proliferation activity in oral and cutaneous canine melanocytic tumours: correlation with histological parameters, location, and clinical behaviour

Research in Veterinary Science
F MillantaA Poli

Abstract

A total of 62 canine melanocytic tumours (10 melanocytomas and 52 primary malignant melanomas) were investigated to compare the accuracy of prognosis provided by MIB-1 proliferation index (MIB-1-PI) with classical histological criteria and location. MIB-1-PI was assessed by means of quantitative image analysis of sections immunostained with MIB-1 monoclonal antibody. Tumour location, histological cell type, stromal or lymphatic vessel invasion, maximum tumour thickness, and presence of inflammation or necrosis were recorded for each case. Thirty-eight dogs were submitted to a 1-year follow-up and the clinical outcome of the disease determined. MIB-1-PI in melanocytomas differed significantly from that detected in primary malignant melanomas (P=0.0001). A significant difference in MIB-1-PI was revealed between oral and cutaneous malignant melanomas (P=0.015), and between presence and absence of lymphatic vessel invasion (P=0.05). MIB-1-PI was not correlated with the other parameters. In univariate analysis, only tumour location (oral vs cutaneous), presence of lymphatic vessel invasion, and MIB-1-PI were associated with decreased overall survival (P=0.0001,P=0.0144, and P=0.0489, respectively). In conclusion, the results of our ...Continue Reading

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Citations

Oct 16, 2013·Veterinary Research Communications·Tarso Felipe TeixeiraMaria Lucia Zaidan Dagli
Jan 26, 2016·Veterinary Ophthalmology·K Tomo WiggansDavid J Maggs
Jun 6, 2013·Veterinary Pathology·C CampagneG Egidy
Dec 3, 2010·Veterinary Pathology·I L BerginM Kiupel
Oct 7, 2017·The Veterinary Quarterly·Owen DaviesAna Lara-Garcia
Apr 24, 2018·The Journal of Veterinary Medical Science·Kengo UedaKiyokazu Ozaki
May 5, 2020·Journal of the American Veterinary Medical Association·Kenneth A CarrollAndrew Dunn
Jun 25, 2020·Veterinary Pathology·Serenella SilvestriChiara Brachelente
Jan 31, 2020·BMC Veterinary Research·Emerson Soares VelosoEnio Ferreira
Jul 15, 2020·BMC Veterinary Research·María José García-IglesiasClaudia Pérez-Martínez
Mar 10, 2021·Veterinary Pathology·Stefano Di PalmaMike Starkey
Jan 12, 2022·Journal of Veterinary Dentistry·Matthew L RaleighKendall Taney

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