Proliferation and apoptosis of T lymphocytes in patients with bipolar disorder

Scientific Reports
Krzysztof PietruczukJacek M Witkowski

Abstract

The aim of the study was to evaluate proliferation capacity and susceptibility to apoptosis of T lymphocytes of patients with bipolar disorder (BD) and to investigate in vitro influence of two standard mood stabilizers: lithium and valproic acid on these parameters using flow cytometry. Our results show that T lymphocytes of BD patients, especially those treated with lithium, have reduced proliferation capacity compared to healthy people. In vitro studies showed that valproic acid reduces the number of cell divisions and percentages of proliferating cells regardless of health status but mainly in very high dose, while lithium has no significant influence on proliferation capacity of patients' T lymphocytes. Lymphocytes of BD patients are also more prone to apoptosis compared with healthy individuals which is related to high expression of Bax, a pro-apoptotic protein. In vitro lithium protected patients' lymphocytes from apoptosis proportionally to dose used. Valproic acid protected lymphocytes of patients from apoptosis mainly in therapeutic concentration. Our results show that mood stabilizers used to prevent relapses of the disease have anti-apoptotic effect on T lymphocytes of BD patients but they are not able to improve the...Continue Reading

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Citations

Nov 13, 2019·Current Pharmaceutical Design·Jacek M WitkowskiTamas Fulop
Apr 30, 2019·Archivum Immunologiae Et Therapiae Experimentalis·Łukasz P SzałachWiesław J Cubała
Aug 28, 2020·Frontiers in Oncology·Anastasios Dimou, Konstantinos N Syrigos
Apr 12, 2019·Scientific Reports·Krzysztof PietruczukJacek M Witkowski
Jan 10, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Esmé Jansen van VurenBrian H Harvey
Mar 7, 2021·Brain Sciences·Bianca Wollenhaupt-AguiarBianca Pfaffenseller
Jul 29, 2021·Progress in Neuro-psychopharmacology & Biological Psychiatry·Florian KrullOle A Andreassen

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Methods Mentioned

BETA
pharmacotherapy
PCR

Software Mentioned

PikoReal
FlowJo X
Statistica

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