PMID: 8583146Nov 1, 1995Paper

Proliferation and differentiation of a human hepatoblastoma transplanted in the Nude mouse

Journal of Hepatology
C DesdouetsJ Sobczak-Thépot

Abstract

A pure epithelial human hepatoblastoma was directly transplanted to athymic Nude mice to provide a model system to study proliferation and differentiation of these tumoral cells. The first transplantation selected the embryonal component of this tumor, while subsequent passages selected in addition neuroendocrine and mesenchymal cells that evolved into osteoid and bony trabeculae. The embryonal character of this hepatoblastoma was further demonstrated by the expression of glutamine synthetase mRNA and a fetal pattern of mRNAs encoding insulin-like growth factor II. However, alphafetoprotein mRNA was detectable in neither the original nor the transplanted tumors. Finally, although p53 mRNA levels were increased, no mutation was detected in the p53 gene.

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Citations

Aug 10, 2012·World Journal of Gastroenterology : WJG·Shinsuke FujiwaraKatsutoshi Yoshizato
Apr 28, 2016·Journal of Hepatology·Beatrice Bissig-ChoisatKarl-Dimiter Bissig
Mar 26, 2015·PloS One·Katharina BertramAgnes Görlach
Apr 27, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Delphine NicolleStefano Cairo
Jan 26, 2020·Cancers·Richard S WhitlockSarah E Woodfield
Jan 20, 2020·Journal of Hepatology·Erin BresnahanAmaia Lujambio

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