Proliferation and differentiation of neural stem cells irradiated with X-rays in logarithmic growth phase

Neuroscience Research
Mayu IsonoNobuo Inoue

Abstract

Exposure of the fetal brain to ionizing radiation causes congenital brain abnormalities. Normal brain formation requires regionally and temporally appropriate proliferation and differentiation of neural stem cells (NSCs) into neurons and glia. Here, we investigated the effects of X-irradiation on proliferating homogenous NSCs prepared from mouse ES cells. Cells irradiated with X-rays at a dose of 1Gy maintained the capabilities for proliferation and differentiation but stopped proliferation temporarily. In contrast, the cells ceased proliferation following irradiation at a dose of >5Gy. These results suggest that irradiation of the fetal brain at relatively low doses may cause congenital brain abnormalities as with relatively high doses.

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Citations

Apr 29, 2015·International Journal of Radiation Biology·Hyeon Soo EomUhee Jung
Apr 8, 2014·Radiation Research·Jung-Hoon PyoMi-Ae Yoo
Dec 30, 2014·Cellular and Molecular Neurobiology·Natália KokošováBeňadik Šmajda
Jan 24, 2018·Stem Cells International·Lixiang Huang, Gan Wang
Nov 27, 2014·World Journal of Stem Cells·Masahiro OtsuNobuo Inoue
Sep 12, 2019·International Journal of Radiation Biology·Danijela StanisavljevicMilena Stevanovic
May 14, 2021·Journal of Radiation Research·Mahesh BekalTakashi Moritake

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