PMID: 8597811Mar 1, 1995Paper

Proliferation and maturation indices in nephrogenic rests and Wilms tumor; the emergence of heterogeneity from dormant nodular renal blastema

Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
K E BoveB K Debrosse

Abstract

Independent nephrogenic rests (NRs) accompany many Wilms tumors (WTs), exhibit a range of qualities suggesting dormancy, maturation, regression, and hyperplasia, and may carry the WT-1 mutation. We assessed nucleolar organizer regions, proliferating cell nuclear antigen (PCNA) activity, cytoplasmic filament expression, and nuclear morphology in 79 nephrogenic rests accompanying 20 WTs. We found a direct relationship between the size of a blastematous NR and the AgNOR number per nucleus and a close correlation with PCNA activity. The blastema of most NRs > 1 cm in diameter was indistinguishable from blastema of most WTs. The smallest NR usually had a low number of silver-reactive nucleolar organizing regions (AgNORs), low PCNA activity, and absent cytoplasmic filaments, all characteristics of a nascent dormant state in which both proliferation rate and protein synthetic activity are low. Intermediate filament expression was variable in blastema of larger NRs; cytoplasmic filaments correlated with emergence of epithelial maturation and absence of filaments with accumulation of immature cells; mature epithelial structures in NRs had low AgNOR number and PCNA activity representing a terminal dormant state. The majority of blastemal...Continue Reading

References

May 1, 1990·Ultrastructural Pathology·M DerenziniA Cancellieri
May 1, 1990·Journal of Clinical Pathology·E Sivridis, B Sims
Jan 1, 1991·Acta histochemica·G KorekK Wenzelides
Jan 1, 1991·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·B DelahuntF K Mostofi
Jan 1, 1991·The Journal of Pathology·B DelahuntP B Bethwaite
Jan 1, 1990·Pediatric Pathology·J B BeckwithJ F Bonadio
Dec 1, 1990·The American Journal of Surgical Pathology·J Deschênes, N Weidner
Nov 1, 1990·Journal of Clinical Pathology·J Crocker
Jul 1, 1986·The Journal of Urology·R CraverM Nigro
Aug 1, 1969·Cancer·K E BoveA J McAdams
Apr 1, 1981·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·S M HsuH Fanger
Jan 1, 1984·International Review of Cytology·G Goessens

❮ Previous
Next ❯

Citations

Jan 1, 2010·Current Gerontology and Geriatrics Research·Robert D YoungThomas T Perls
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Raisa VuononvirtaChris Jones
Apr 12, 2011·African Journal of Paediatric Surgery : AJPS·A J W MillarFarieda Desai
Sep 15, 2001·Advances in Anatomic Pathology·R A HennigarJ D Grattan-Smith
Mar 1, 2005·Journal of Periodontology·Takaaki TomofujiTakashi Kishimoto
Mar 17, 2004·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Francesca Diomedi CamasseiCarlo Dominici

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
J G van der StegeB Arabin
Pediatric Pathology & Laboratory Medicine : Journal of the Society for Pediatric Pathology, Affiliated with the International Paediatric Pathology Association
G M VujanićJ F Delemarre
© 2021 Meta ULC. All rights reserved