PMID: 22333516Feb 16, 2012Paper

Proliferation capacity, neuronal differentiation potency and microstructures after the differentiation of canine bone marrow stromal cells into neurons

The Journal of Veterinary Medical Science
Kazuya EdamuraShigeo Tanaka

Abstract

We examined the proliferation capacity and neuronal differentiation potency of canine bone marrow stromal cells (BMSCs). In addition, the microstructures of neuron-like cells after neuronal differentiation were observed under a scanning electron microscope. Canine BMSCs grew to confluency at 10.0 ± 2.5 days, and 3.8 ± 2.1 × 10(6) BMSCs were collected in one passage. Approximately 65% of canine BMSCs changed to neuron-like morphology after neuronal differentiation, and nearly all neuron-like cells stained positive against neuron-specific enolase. In addition, microstructures such as the cellular organelles, filaments and growth cones of these cells bore a close resemblance to those of the original mature neurons. These results suggested that canine BMSCs might be capable of differentiating into neurons.

References

Aug 1, 2000·Experimental Neurology·J Sanchez-RamosP R Sanberg
Aug 10, 2000·Journal of Neuroscience Research·D WoodburyI B Black
Feb 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·C P HofstetterL Olson
Aug 6, 2002·Experimental Hematology·Douglas R MartinHenry J Baker
Oct 13, 2005·Brain : a Journal of Neurology·F FéronA Mackay-Sim
Nov 3, 2006·American Journal of Veterinary Research·Hiroaki KamishinaRoger M Clemmons
Apr 10, 2008·In Vitro Cellular & Developmental Biology. Animal·Hiroaki KamishinaRoger M Clemmons
Aug 25, 2010·The Veterinary Clinics of North America. Small Animal Practice·Natasha Olby
Oct 14, 2010·BMJ : British Medical Journal·Susan Mayor

❮ Previous
Next ❯

Citations

Feb 25, 2014·The Journal of Veterinary Medical Science·Yasutaka OdaYasuho Taura
Feb 26, 2013·Veterinary Research Communications·Yasutaka OdaYasuho Taura
May 1, 2018·Journal of Molecular Neuroscience : MN·Nicole JungwirthFlorian Hansmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.