PMID: 6162564Jan 1, 1981Paper

Proliferation inhibition of murine pluripotent haemopoietic stem cells by interferon or poly I:C

Cell and Tissue Kinetics
J GidáliM Tálas

Abstract

The effect of mouse serum interferon (IF) in vitro and an inducer in vivo on the proliferation of a pluripotent stem cell population with high turnover rate was studied. Proliferation rate was characterized by the number of CFUs in the S phase of the cell cycle. Increased proliferation of bone marrow stem cell populations was produced either by irradiating the donor mice with 3.36 Gy (336 rad) 60Co-gamma rays 7 days before the experiment or by incubating normal bone marrow cells with 10(-11) M concentration of isoproterenol. IF considerably reduced the number of CFUs in S phase in both cases without reducing the CFUs content of the samples. Injection of IF inducer (4 mg/kg poly I:C) into regenerating mice also inhibited the proliferation of CFUs without decreasing the femoral CFUs level. Regeneration kinetics of CFUs from irradiated poly I:C-treated mice ran parallel with that of irradiated untreated animals but showed a characteristic delay corresponding to approximately one CFUs doubling. A transient, non-cytotoxic proliferation inhibitory effect of IF or IF inducer is, therefore, proposed.

References

Nov 1, 1977·The Journal of Cell Biology·G P Matarese, G B Rossi
Dec 1, 1977·Cellular Immunology·I Gresser
Aug 24, 1978·Nature·F Balkwill, J Taylor-Papadimitriou
Aug 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·I GresserA Macieira-Coelho
Jul 20, 1973·Nature·H KeshishyanE Jawetz
Jan 1, 1972·Archiv für die gesamte Virusforschung·M TálasG Koczkás

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Citations

Jan 1, 1984·Journal of Interferon Research·R C FuhlbriggeE C Borden

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