Proliferation kinetics of the mouse bladder after irradiation
Abstract
The proliferation response of the mouse bladder was investigated, using continuous labelling with tritiated thymidine, at various times after a single dose of radiation. Bladder epithelial and vascular endothelial cells were studied. The cell turnover rate in unirradiated epithelium and endothelium was found to be extremely slow (in excess of 1 year). Irradiation with a single dose of 25 Gy resulted in compensatory proliferation of the epithelium but the response was not initiated for many months. At 3 months after irradiation there was little difference from the control proliferation rate, but from 6 to 22 months after irradiation (the end of the study) there was a period of sustained rapid proliferation with the cell turnover time reduced to approximately 1 week. The increase in proliferative activity observed at 22 months was found to be dose-dependent. Endothelial cells in the blood vessels of the submucosa also showed an increased turnover rate after irradiation and the timing this response was found to be similar to that of the epithelium. The onset of compensatory proliferation in both cell types was found to coincide with marked histological and functional changes in the bladder. In this slowly proliferating tissue, the...Continue Reading
References
Citations
A feasibility study of accelerated fractionation in radiotherapy of carcinoma of the urinary bladder
Acute and late radiation damage in mouse bladder: a comparison of urination frequency and cystometry
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