PMID: 7371060Jan 1, 1980Paper

Proliferation kinetics of the mouse bladder after irradiation

Cell and Tissue Kinetics
F A StewartD G Hirst

Abstract

The proliferation response of the mouse bladder was investigated, using continuous labelling with tritiated thymidine, at various times after a single dose of radiation. Bladder epithelial and vascular endothelial cells were studied. The cell turnover rate in unirradiated epithelium and endothelium was found to be extremely slow (in excess of 1 year). Irradiation with a single dose of 25 Gy resulted in compensatory proliferation of the epithelium but the response was not initiated for many months. At 3 months after irradiation there was little difference from the control proliferation rate, but from 6 to 22 months after irradiation (the end of the study) there was a period of sustained rapid proliferation with the cell turnover time reduced to approximately 1 week. The increase in proliferative activity observed at 22 months was found to be dose-dependent. Endothelial cells in the blood vessels of the submucosa also showed an increased turnover rate after irradiation and the timing this response was found to be similar to that of the epithelium. The onset of compensatory proliferation in both cell types was found to coincide with marked histological and functional changes in the bladder. In this slowly proliferating tissue, the...Continue Reading

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Jan 1, 1973·The British Journal of Radiology·H S Reinhold, G H Buisman
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Citations

Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·S QuarmbyS Kumar
Jan 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J G PostF A Stewart
Nov 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J G PostF A Stewart
Mar 30, 1995·International Journal of Radiation Oncology, Biology, Physics·L B MarksM S Anscher
Feb 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L MoonenH Bartelink
Apr 1, 1993·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·F LundbeckF Stewart
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S P Jost
Jan 1, 1989·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·S P Jost
Jan 1, 1984·Acta Radiologica. Oncology·J Denekamp
Nov 17, 2015·Urology·Bernadette M M ZwaansLaura E Lamb
Oct 1, 1984·International Journal of Radiation Oncology, Biology, Physics·M V PilepichB J Walz
Oct 1, 1991·International Journal of Radiation Oncology, Biology, Physics·F A StewartA Luts
Aug 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F A StewartB D Michael
Mar 1, 1984·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·M V Williams, J Denekamp
Dec 1, 1985·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·F A Stewart
Jun 1, 1984·The Journal of Pathology·G N AntonakopoulosR J Berry
Apr 1, 1988·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·G EdreesF Stewart
Sep 1, 1981·The British Journal of Radiology·F A StewartJ Denekamp
Aug 1, 1989·The British Journal of Radiology·J F Fowler
Jun 23, 2006·Physics in Medicine and Biology·Jack F Fowler
May 26, 2009·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Oktay IrkorucuMustafa Comert
Dec 23, 1999·The Journal of Biological Chemistry·J R Saam, J I Gordon
Jun 16, 2021·International Journal of Radiation Biology·Marjan BoermaJacqueline P Williams

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