Proliferation of B cells from chronic lymphocytic leukemia is selectively promoted by B cell growth factor

Acta Haematologica
M Alvarez-MonA Durantez

Abstract

B cell activation was studied in B cells from B cell chronic lymphocytic leukemia (B-CLL) patients. After in vitro stimulation, these B cells showed extensive proliferation in the presence of high-molecular-weight B cell growth factor (BCGF). In contrast, this effect was not observed upon addition of recombinant interleukin-2 (IL-2). In agreement, upon stimulation, B cells expressed Bac-1 antigen but failed to acquire the IL-2 receptor. These results demonstrate that the utilization of the BCGF pathway can be segregated from that of IL-2 in B cells from B-CLL patients.

Citations

May 1, 1995·Journal of Clinical Pathology·T Mainou-FowlerA G Prentice
Sep 1, 1994·Leukemia & Lymphoma·S PetraschM Kosco-Vilbois
May 1, 1996·Leukemia & Lymphoma·T Mainou-Fowler, A G Prentice
Aug 1, 1994·Endocrine Research·M MarazuelaM Alvarez-Mon
Sep 1, 1991·The Journal of Pediatrics·L SanchoM Alvarez-Mon

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