PMID: 8952339Jan 1, 1996Paper

Proliferation of cancer cells and stromal cells in colorectal adenocarcinomas as assessed with anti-PCNA/cyclin monoclonal antibody

Polish Journal of Pathology : Official Journal of the Polish Society of Pathologists
M MarkiewskiW Domagała

Abstract

Monoclonal anti-proliferating cell nuclear antigen antibody (PCNA, PC 10) was used to measure proliferation of tumor cells and stromal cells in 27 colorectal adenocarcinomas. Mean proliferation index of cancer cells was 33.7% (SD +/- 16.3) and that of stromal cells 14.3 (SD +/- 12.5). Positive correlation between proliferation index of cancer cells and proliferation rate of stromal cells was found (r = 0.64, p < 0.001). Correlation between proliferation of stromal lymphocyte-like cells and fibroblast-like cells was noticed (r = 0.69, p < 0.001).

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.