PMID: 11071041Nov 9, 2000Paper

Proliferation of mitochondria and gene expression of carnitine palmitoyltransferase and fatty acyl-CoA oxidase in rat skeletal muscle, heart and liver by hypolipidemic fatty acids

Biology of the Cell
G K TotlandR K Berge

Abstract

Morphological and biochemical effects were induced at the subcellular level in the skeletal muscle, heart and liver of male rats as a result of feeding with EPA, DHA, and 3-thia fatty acids. The 3-thia fatty acid, tetradecylthioacetic acid (TTA) and EPA induced mitochondrial growth in type I muscle fibers in both the diaphragm and soleus muscle, and the size distribution of mitochondrial areas followed a similar pattern. Only the 3-thia fatty acid induced mitochondrial growth in type II muscle fibers. The mean area occupied by the mitochondria and the size distribution of mitochondrial areas in both fiber types were highly similar in DHA-treated and control animals. Only the 3-thia fatty acid increased the gene-expression of carnitine palmitoyltransferase (CPT)-II in the diaphragm. In the heart, however, the gene expression decreased. In hepatocytes an increase in the mean size of mitochondria was observed after EPA treatment, concomitant with an increase in mitochondrial CPT-II gene expression. Administration of 2-methyl-substituted EPA (methyl-EPA) induced a higher rate of growth of mitochondria than EPA. At the peroxisomal level in the hepatocytes a 3-thia fatty acid, EPA, and DHA increased the areal fraction concomitant wit...Continue Reading

References

Jun 22, 1992·Biochimica Et Biophysica Acta·M E SuretteJ E Kinsella
May 1, 1988·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H J GundersenA Vesterby
Jan 21, 1997·Biochimica Et Biophysica Acta·S SkredeJ Bremer
Feb 15, 1997·European Journal of Biochemistry·J D McGarry, N F Brown
Apr 29, 1997·Proceedings of the National Academy of Sciences of the United States of America·B M FormanR M Evans
Jul 17, 1999·The American Journal of the Medical Sciences·R R Ramsay

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Citations

Jun 6, 2009·Cardiovascular Research·Le ChenAnne A Knowlton
Jun 5, 2002·Current Opinion in Lipidology·Rolf K BergeHans Grav
May 17, 2007·Epilepsy Currents·Jong M Rho, Michael A Rogawski
Oct 22, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Brennan K SmithDavid W L Ma
Jul 24, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Christopher J GerlingLawrence L Spriet
May 10, 2011·Prostaglandins, Leukotrienes, and Essential Fatty Acids·G H ThoresenA C Rustan
Jun 14, 2005·Biochimica Et Biophysica Acta·Lise MadsenKarsten Kristiansen
Feb 22, 2017·Biological Reviews of the Cambridge Philosophical Society·Juan M ZolezziNibaldo C Inestrosa
Feb 2, 2011·Therapeutic Advances in Cardiovascular Disease·Laura C J PôrtoLeida M Botion
Apr 13, 2004·Current Opinion in Clinical Nutrition and Metabolic Care·Alexandre LapillonneWilliam C Heird
Nov 4, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Zane ChornerGraham P Holloway
Feb 5, 2008·Journal of Neuroscience Research·Laurie M DavisPatrick G Sullivan
Feb 29, 2008·Molecular Nutrition & Food Research·Jing-Jing LiDong Xie
Nov 19, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Elizabeth M NovakSheila M Innis
Jul 1, 2006·The Journal of Experimental Biology·Dominique Maillet, Jean-Michel Weber
Sep 15, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ellen Johanne KlevelandTor Gjøen

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