Proliferation of normal and leukemic TdT+ bone marrow cells in man

Leukemia Research
A Hirt, H P Wagner

Abstract

Proliferative characteristics of lymphoid cells with detectable amounts of nuclear terminal deoxynucleotidyl transferase (TdT) in normal or regenerating non-leukemic bone marrow of children were assessed by sequential immunological and cytokinetic studies on single cells and compared to those of TdT+ cells in the bone marrow of children with non-T, non-B acute lymphoid leukemia (ALL) at diagnosis or in remission. The median labelling index (LI) of non-leukemic TdT+ cells was 21.3% (range 13.2 to 29.7%). The LI of non-leukemic TdT+Ia+ cells (range 18.2 to 32.6%) was always higher than that of non-leukemic TdT+Ia- cells (range 0 to 5.3%). Leukemic TdT+ bone marrow cells of children with previously untreated non-T, non-B ALL had a LI significantly (p less than 0.001) lower (median 6.1%; range 1.4 to 19.7%) than the LI of non-leukemic TdT+ cells. In patients with non-T, non-B ALL in remission neither the percentage of TdT+ cells nor the LI of TdT+ cells appeared to be useful for detecting early relapse.

References

Aug 1, 1976·The Journal of Experimental Medicine·A E SilverstoneD Baltimore
Sep 25, 1981·Science·J Dausset
Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·S SarkarO W Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.