Proliferation of rat astrocytes, but not of oligodendrocytes, is stimulated in vitro by protease inhibitors

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
F PerraudM Sensenbrenner

Abstract

Various natural protease inhibitors stimulate the proliferation of rat astrocytes grown in primary culture in the absence of serum. They are inactive on the proliferation of oligodendrocytes. The mean level of stimulation of the astrocyte proliferation elicited by the protease inhibitors is higher when the cells are in the growth phase, at low cell density than when they are quiescent, at high cell density. Among the protease inhibitors tested three serum proteins, alpha 1-antitrypsin, alpha 2-macroglobulin and anti-thrombin III were the most active. The present results, taken together with our previous finding that thrombin and some other proteases also stimulate the proliferation of astroglial cells but not of oligodendroglial cells, suggest that proteases and protease inhibitors participate, through still unclear mechanisms, in the control of the proliferation of astrocytes, but not in that of oligodendrocytes, during brain ontogenesis.

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·R E MillerH Gershman
Dec 21, 1979·Brain Research·G LabourdetteJ L Nussbaum
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L B Chen, J M Buchanan
Mar 22, 1976·Biochemical and Biophysical Research Communications·B Westermark
Jan 1, 1987·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F PerraudG Labourdette
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J LindnerD Monard
Feb 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·F A McMorrisR W Furlanetto
Feb 1, 1986·Journal of Neurocytology·H ReynersJ R Maisin
Sep 9, 1985·FEBS Letters·B PettmannG Labourdette
Jun 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·D MonardR Gysin
Jan 1, 1971·Analytical Biochemistry·R T Hinegardner
Jul 1, 1980·Neurochemical Research·K Iqbal, J H Ottaway
Jan 1, 1983·Annual Review of Biochemistry·J Travis, G S Salvesen
Jun 1, 1980·The Journal of Cell Biology·K D McCarthy, J de Vellis
Sep 1, 1984·Brain Research·P A Eccleston, D H Silberberg
Apr 1, 1981·Cell Biology International Reports·R Pérez-RodriquezJ Pouysségur
Jan 1, 1981·Developmental Neuroscience·B PettmannM Sensenbrenner
Jan 1, 1984·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M WeibelM Sensenbrenner
Jan 1, 1985·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M WeibelM Sensenbrenner

❮ Previous
Next ❯

Citations

Apr 19, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ivan MilenkovicAndreas Bringmann
Oct 15, 1992·Clinica Chimica Acta; International Journal of Clinical Chemistry·S A Back, J A Alhadeff
Jul 1, 1998·Brain Research. Molecular Brain Research·P Tryoen-TothG Labourdette
Aug 1, 1991·Journal of Neurochemistry·J N WhitakerE N Benveniste
Jun 1, 1997·Glia·C Jacquin-Becker, G Labourdette
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·A V HillS C Gilbert
Jun 5, 1998·The American Journal of Physiology·O DéryN W Bunnett

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
F BesnardG Labourdette
Clinica Chimica Acta; International Journal of Clinical Chemistry
S A BackJ A Alhadeff
Cell Differentiation and Development : the Official Journal of the International Society of Developmental Biologists
C LoretG Labourdette
© 2021 Meta ULC. All rights reserved