Proliferation of vascular smooth muscle cells in glioblastoma multiforme

Journal of Neurosurgery
Hiroaki TakeuchiKen-ichiro Kikuta

Abstract

Glioblastomas multiforme (GBM) contain a higher number of alpha-smooth muscle actin (SMA)-positive vascular smooth muscle cells (VSMCs) than those in the respective normal neuronal tissue. The role of VSMCs during angiogenesis is unclear, and it is also uncertain whether and to what extent angiogenic factors might be involved in GBM VSMCs. In GBMs, the contribution of VSMCs in angiogenesis accompanying endothelial proliferation and the correlation of VSMC proliferation with vascular endothelial growth factor (VEGF) expression were examined using an immunohistochemical method. The examined material, including surrounding brain tissue, came from 12 cases (6 men and 6 women) with classic GBM. Microvessel densities (MVDs) of CD31-immunoreactive vessels (CD31-MVD) and SMA-immunoreactive vessels (SMA-MVD) were obtained in areas selected from white matter, boundary, tumor (concentrated area of tumor cells), and perinecrosis. Subsequently, the SMA-MVD/CD31-MVD (SMA/CD31) rate, representing the percentage of vessels with VSMCs in the region, was calculated in each area. The VEGF immunoreactivity of tumor cells was examined, and cases were divided into 2 groups: < 30% VEGF expression of tumor cells (low VEGF group) and > 30% VEGF express...Continue Reading

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Citations

Nov 22, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Nunung Nur RahmahKazuhiro Hongo
Feb 2, 2018·Molecular Cancer·Guiling WuYang Yang
Jan 5, 2016·Journal of Neuro-oncology·Hiroaki TakeuchiHirohiko Kimura
Sep 24, 2019·Future Medicinal Chemistry·Raul OrtizJose Prados

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Methods Mentioned

BETA
SMA

Software Mentioned

Mac Scope

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