Proliferation patterns in the canine endometrium during the estrous cycle

Theriogenology
S Van CruchtenP Simoens

Abstract

The proliferative activity in the endometrium of 58 bitches in different stages of the estrous cycle was assessed by immunohistochemical detection of the Ki-67 proliferation associated nuclear antigen and by counting mitotic figures. The Ki-67 labelling index and the mitotic index were determined in the surface epithelium, the stroma, the crypts and the basal glands by calculating the percentage of Ki-67 positive cells and mitotic figures, respectively, on a total of 500 cells of each category. Endometrial vascular proliferation was also verified by counting the number of Ki-67 positive cells on a total of 100 endothelial cells. The present study showed two proliferation peaks involving different cell groups. In the surface epithelium, the stroma, the blood vessels and the crypts, the highest labelling and mitotic indexes were noticed during proestrus, whereas for the basal glands these indexes significantly increased (P < 0.05) during estrus compared to late metestrus and anestrus. Furthermore, a slightly positive correlation (P < 0.05) was found between the labelling index in the basal glands and the serum progesterone levels, whereas the labelling indexes in the other cell groups were positively correlated with the estradiol...Continue Reading

References

Jan 1, 1975·Annual Review of Physiology·R M Brenner, N B West
May 1, 1975·The American Journal of Anatomy·M D BarrauW J Tietz
Sep 1, 1979·Biology of Reproduction·J L KirklandG M Stancel
Jan 11, 1975·The American Journal of Anatomy·M D BarrauW J Tietz
Nov 1, 1994·Journal of Clinical Pathology·D S RoseD C Brown
Jul 1, 1997·Journal of Reproduction and Fertility·A G Gunin
May 26, 1999·The Journal of Veterinary Medical Science·K Nomura, H Funahashi
Oct 3, 1999·Journal of Reproduction and Fertility·C GerstenbergF Stewart
Mar 1, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·B Heryanto, P A W Rogers
Mar 8, 2002·Reproduction : the Official Journal of the Society for the Study of Fertility·Po-yin Chu PyP J Wright
Jun 20, 2002·Reproduction in Domestic Animals = Zuchthygiene·S Van CruchtenH Lauwers
Feb 5, 2003·Cells, Tissues, Organs·S Van CruchtenP Simoens
Oct 29, 2003·Theriogenology·S Van CruchtenP Simoens

❮ Previous
Next ❯

Citations

Nov 28, 2008·In Vitro Cellular & Developmental Biology. Animal·K StadlerI Walter
Sep 21, 2013·Animal Reproduction Science·Miki AraiKiyoshi Okuda
Nov 28, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Magdalena GajęckaMaciej Gajęcki
Nov 9, 2010·Animal Reproduction Science·Patrick W Concannon
Nov 8, 2007·Reproduction in Domestic Animals = Zuchthygiene·B A SchotanusA C Okkens
Jun 16, 2007·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Sabine RehmAnn M Williams
Oct 1, 2010·Reproduction in Domestic Animals = Zuchthygiene·R Payan-CarreiraH Rodriguez-Martinez
Apr 27, 2013·Anatomia, histologia, embryologia·C BartelI Walter
Aug 4, 2015·Reproduction in Domestic Animals = Zuchthygiene·M A Pires, R Payan-Carreira
Feb 25, 2015·Reproduction, Fertility, and Development·S HenriquesL Mateus
Nov 4, 2016·Reproduction in Domestic Animals = Zuchthygiene·I B NogueiraC I Vannucchi
Aug 17, 2017·Anais Da Academia Brasileira De Ciências·Vanessa S A GosslerInes C Giometti
Jan 21, 2021·Animals : an Open Access Journal From MDPI·Alba MartíMaria Montserrat Rivera Del Alamo
Apr 30, 2021·Reproduction in Domestic Animals = Zuchthygiene·Chunsumon LimmanontKaitkanoke Sirinarumitr

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis