Proliferation patterns in the canine endometrium during the estrous cycle
Abstract
The proliferative activity in the endometrium of 58 bitches in different stages of the estrous cycle was assessed by immunohistochemical detection of the Ki-67 proliferation associated nuclear antigen and by counting mitotic figures. The Ki-67 labelling index and the mitotic index were determined in the surface epithelium, the stroma, the crypts and the basal glands by calculating the percentage of Ki-67 positive cells and mitotic figures, respectively, on a total of 500 cells of each category. Endometrial vascular proliferation was also verified by counting the number of Ki-67 positive cells on a total of 100 endothelial cells. The present study showed two proliferation peaks involving different cell groups. In the surface epithelium, the stroma, the blood vessels and the crypts, the highest labelling and mitotic indexes were noticed during proestrus, whereas for the basal glands these indexes significantly increased (P < 0.05) during estrus compared to late metestrus and anestrus. Furthermore, a slightly positive correlation (P < 0.05) was found between the labelling index in the basal glands and the serum progesterone levels, whereas the labelling indexes in the other cell groups were positively correlated with the estradiol...Continue Reading
References
The time-course of the mitotic response to oestrogen in the epithelia and stroma of the mouse uterus
Hypertrophy and hyperplasia in the mouse uterus after oestrogen treatment: an autoradiographic study
Effect of oestradiol on cell proliferation and histological changes in the uterus and vagina of mice
Cell proliferation patterns in the equine endometrium throughout the non-pregnant reproductive cycle
Citations
Distribution of superoxide dismutase 1 and glutathione peroxidase 1 in the cyclic canine endometrium
Uterine haemodynamic, vascularization and blood pressure changes along the oestrous cycle in bitches
The effect of experimental low zearalenone intoxication on ovarian follicles in pre-pubertal bitches
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Apoptosis
Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis