Proliferation, steroid receptors and clinical/pathological response in breast cancer treated with letrozole

British Journal of Cancer
W R MillerT J Anderson

Abstract

Sixty-three postmenopausal women with large primary breast cancers were treated with neoadjuvant letrozole (2.5 mg daily) for 3 months. Tumour samples were taken at diagnosis and after 10-14 days and 3 months treatment. Immunohistochemical staining for Ki67, oestrogen receptor (ER) and progesterone receptor (PgR) was performed and related to clinical (ClinR) and pathological responses (PathR) after 3 months treatment. ClinR was observed in 48 of 63 cases (76.2%) and PathR in 47 of 62 (75.8%). Pretreatment Ki67 scores were similar in responders (R) and non-responders (NR). Highly significant Ki67 decreases occurred in all tumour subgroups at 10-14 days (P<0.005). A significant difference in Ki67 scores at 10-14 days (P<0.007) was found between PathR and PathNR but not between ClinR and ClinNR. At 3 months, decreases from pretreatment Ki67 scores were highly significant in all tumour subgroups irrespective of response status. However, whereas Ki67 scores were significantly different between pathological R and NR (P = 0.009), the corresponding comparison of ClinR status was not. Significant decreases between 10-14 days and 3 months were found only in ClinR and PathR (P = 0.02 and 0.045, respectively). Treatment significantly reduc...Continue Reading

References

Apr 1, 1994·Human Pathology·J J Going
Aug 21, 2001·Breast Cancer Research and Treatment·J M DixonW R Miller
Feb 2, 2002·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W EiermannUNKNOWN Letrozole Neo-Adjuvant Breast Cancer Study Group
Feb 15, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Catherine L Harper-WynneMitchell Dowsett
May 20, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·W R MillerT J Anderson
Oct 15, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C RoseR Lang
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard J SantenRakesh Kumar
Feb 18, 2004·The Breast : Official Journal of the European Society of Mastology·S IqbalW R Miller
Mar 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Mitch DowsettIan E Smith
Jul 19, 2005·The Journal of Steroid Biochemistry and Molecular Biology·J Michael DixonWilliam R Miller

❮ Previous
Next ❯

Citations

Nov 21, 2007·Breast Cancer Research and Treatment·Matthew J Ellis, Cynthia Ma
Jul 23, 2008·BMC Cancer·Paolo Ubezio, David Cameron
Nov 5, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giuseppe VialeUNKNOWN Breast International Group Trial 1-98
Sep 15, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ann A LazarRichard D Gelber
Nov 12, 2009·Future Oncology·Alexey A Larionov, William R Miller
Jan 27, 2012·Breast Cancer Research : BCR·William R Miller, Alexey A Larionov
Nov 2, 2011·Journal of the National Cancer Institute. Monographs·William R Miller, Alexey A Larionov
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William R MillerJ Michael Dixon
Oct 24, 2015·Clinical Trials : Journal of the Society for Clinical Trials·Ann A LazarRichard D Gelber
Sep 22, 2007·Pharmacogenetics and Genomics·William R MillerJohn Michael Dixon
Mar 28, 2008·Expert Review of Anticancer Therapy·J Michael Dixon
May 26, 2010·Expert Opinion on Pharmacotherapy·William R Miller
May 1, 2011·Expert Review of Endocrinology & Metabolism·William R Miller
Apr 15, 2011·Journal of Veterinary Internal Medicine·S Guil-LunaJ Martín de Las Mulas
Sep 19, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Konstantin ChristovRonald A Lubet
Apr 24, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Riley A HampschTodd W Miller
Jul 10, 2007·The Journal of Steroid Biochemistry and Molecular Biology·William R MillerJ Michael Dixon
Feb 16, 2010·The Lancet Oncology·Rinat YerushalmiKaren A Gelmon
May 25, 2011·Molecular and Cellular Endocrinology·William R Miller, Alexey Larionov
May 28, 2011·Critical Reviews in Oncology/hematology·Alvaro Moreno-Aspitia

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Software Mentioned

ClinNR
PathNR
PathR

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Steroid Biochemistry and Molecular Biology
W R MillerT J Anderson
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
J M DixonMitch Dowsett
The Journal of Steroid Biochemistry and Molecular Biology
W R MillerJ M Dixon
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
W R MillerT J Anderson
© 2021 Meta ULC. All rights reserved