Proliferative and antiproliferative effects of interferon-gamma and tumor necrosis factor-alpha on cell lines derived from cervical and ovarian malignancies

American Journal of Obstetrics and Gynecology
D G MutchJ L Collins

Abstract

Four human cell lines derived from cervical carcinomas (ME-180, SiHa, HT-3, and MS751) and three human cell lines derived from ovarian carcinomas (SK-OV-3, Caov-3, and NIH:OVCAR-3) were analyzed in vitro to determine the effect of recombinant interferon-gamma and recombinant human tumor necrosis factor-alpha on cell growth and survival. The effects of interferon-gamma, tumor necrosis factor-alpha, and both interferon-gamma and tumor necrosis factor-alpha on cell growth were measured after 24 and 72 hours of incubation by the incorporation of chromium 51. The results of this analysis showed that all seven cell lines were resistant to the antiproliferative action of tumor necrosis factor-alpha, that the growth of most cell lines was inhibited by interferon-gamma by 72 hours of incubation, and that after 72 hours of incubation all cell lines demonstrated a synergistic antiproliferative response to the combination of interferon-gamma and tumor necrosis factor-alpha. However, the effects of these cytokines on cell growth were found to differ among cell lines and varied with the concentration and the duration of incubation. The growth of one cell line (Caov-3) was stimulated by both tumor necrosis factor-alpha and interferon-gamma. T...Continue Reading

References

Jan 1, 1990·Cancer Immunology, Immunotherapy : CII·C B PowellJ L Collins
Feb 1, 1988·The Journal of Clinical Investigation·D R SpriggsD W Kufe
Apr 1, 1987·Journal of Interferon Research·P ScuderiR A Rippe
Aug 1, 1988·American Journal of Clinical Oncology·C E WelanderE A Levin
Jan 1, 1985·Cancer Immunology, Immunotherapy : CII·K A FoonR B Herberman

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Citations

Apr 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M KloucheF Hölzel
Dec 31, 1997·British Journal of Obstetrics and Gynaecology·B C SheuS C Huang
Nov 1, 1995·American Journal of Obstetrics and Gynecology·M Sancho-TelloV J Hunter
Sep 17, 1996·International Journal of Cancer. Journal International Du Cancer·C MarthG Daxenbichler
Feb 20, 2009·Liver International : Official Journal of the International Association for the Study of the Liver·Blendi QesarakuHans Christiansen

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