Proliferative and cytokine responses of human T lymphocytes isolated from human immunodeficiency virus-infected patients to the major surface glycoprotein of Pneumocystis carinii

The Journal of Infectious Diseases
S A TheusPeter D Walzer

Abstract

The current study examined the proliferative capacity and cytokine secretion pattern of peripheral blood mononuclear cells (PBMC) from human immunodeficiency virus type 1 (HIV-1)-infected patients in response to the major surface glycoprotein (MSG) of Pneumocystis carinii. PBMC from AIDS patients with <200 CD4 cells/mL had significantly less proliferative responses to MSG than did healthy controls. Cytokine analysis indicated that interferon-gamma secreted in response to MSG was also significantly less. There was no significant difference in interleukin-4 levels following incubation with MSG between any of the groups; however, all the HIV-infected persons had slightly elevated levels. When the CDC class C3 patients who had a previous episode of P. carinii pneumonia were compared with those who had not had a previous episode, there was a significant increase in the proliferative response to MSG and in interleukin-4 secretion. CDC class C3 patients who had a previous episode of P. carinii pneumonia showed a predominately Th2 response to MSG.

Citations

Jun 2, 2000·AIDS Patient Care and STDs·C SmacchiaE Concia
Jul 21, 2007·The American Journal of Pathology·Steve D SwainAllen G Harmsen
Dec 8, 2004·Journal of Neuroimmunology·Shilpa BuchOpendra Narayan
Feb 2, 2000·Sexually Transmitted Diseases·M E BlockerM E St Louis
Jan 10, 2006·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lauren BrucknerJack Finkelstein
Oct 13, 2006·Current Opinion in Infectious Diseases·R F Miller
Mar 28, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Saidi H KapigaMax Essex
Apr 15, 1999·AIDS·P L VernazzaM S Cohen
Mar 2, 2002·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Hong-Ha M TruongLawrence Corey
Mar 6, 1999·Clinical and Diagnostic Laboratory Immunology·P D Walzer

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