PMID: 8591708Sep 1, 1995Paper

Proliferative diabetic retinopathy is related to cardiovascular autonomic neuropathy in non-insulin-dependent diabetes mellitus

Diabetes Research and Clinical Practice
H SchmidC Neumann

Abstract

The aim of the study was to define the relationship between the presence of proliferative diabetic retinopathy and nephropathy with objectively defined autonomic neuropathy in non-insulin-dependent diabetes mellitus (NIDDM) patients. The research design used was a cross-sectional, case control study. A cohort of NIDDM patients was classified, according to five cardiovascular autonomic tests described by Ewing, as: (1) no involvement--no abnormal tests (n = 17); (2) cardiovascular autonomic neuropathy--two out of five abnormal tests (n = 18). Age, age at diagnosis, plasma creatinine, fasting plasma glucose, glycated haemoglobin and blood pressure measurements were not statistically different among the two groups. According to indirect ophthalmoscopy and the presence of macroproteinuria and microalbuminuria, respectively, patients were also classified as having proliferative, non-proliferative or no retinopathy and with or without nephropathy. The results showed a striking relationship between cardiovascular autonomic neuropathy and proliferative diabetic retinopathy. Relative odds for nephropathy, non-proliferative diabetic retinopathy and proliferative retinopathy were, respectively, 16.0, 10.1 and 34.7. When odds ratios were a...Continue Reading

References

Dec 1, 1992·Diabetes Care·R KleinS E Moss
Jan 1, 1985·Journal of Chronic Diseases·A S KrolewskiA R Christlieb
Sep 1, 1983·Metabolism: Clinical and Experimental·H H ParvingN A Lassen

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Citations

Nov 5, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·M K RutterS M Marshall
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Futoshi AnanHironobu Yoshimatsu
Mar 10, 2016·Journal of Diabetes Research·Chih-Cheng HuangRue-Tsuan Liu
Jun 27, 2006·Journal of Diabetes and Its Complications·Aniz Girach, Louis Vignati
May 17, 2007·Arquivos brasileiros de endocrinologia e metabologia·Helena Schmid

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