PMID: 9420621Jan 8, 1998Paper

Proliferative effect of dextran sulfate sodium (DSS)-pulsed macrophages on T cells from mice with DSS-induced colitis and inhibition of effect by IgG

Scandinavian Journal of Immunology
N ShintaniT Mayumi

Abstract

The authors have previously reported that homologous immunoglobulin (Ig)G reduces the occurrence of dextran sulfate sodium (DSS)-induced colitis, mainly by suppressing recruitment of immunocompetent cells into colitis lesions. However, the mechanisms of cell recruitment and of its suppression by IgG remain unclear. In addressing these questions, this study focused on the activation of T cells in the presence of macrophages. The authors found that [3H]-thymidine uptake of T cells from DSS-induced colitis mice, but not from normal mice, was significantly enhanced when cultured with DSS-pulsed macrophages. From the profile of cytokine production, it was suggested that T helper 1 (Th1)-type cells become predominant during stimulation. Addition of homologous IgG significantly suppressed T cell proliferation in a dose-dependent manner, while no suppressive effect was observed with heterologous IgG. Mouse IgG F(ab')2, but not Fc, fragments partially mimicked the suppressive effect of whole IgG. These findings provide evidence that Th1-type cells may play an important role in the development of DSS-induced colitis and that homologous IgG exerts its protective action at least in part through the F(ab')2 portion.

Citations

Jul 25, 2013·Cancer Letters·George S Wilson, Jacob George
Jun 18, 2015·PloS One·Qi Ying LeanNuri Gueven
Jun 18, 2016·Archives of Toxicology·Aya M WestbrookRobert H Schiestl
Aug 7, 2003·Inflammatory Bowel Diseases·Atsushi MizoguchiAtul K Bhan
Jan 18, 2011·Experimental Biology and Medicine·Charles S JohnsonJesse M Hostetter
Oct 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bradford E BerndtJohn Y Kao
Jun 3, 2009·Cancer Research·Aya M WestbrookRobert H Schiestl

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