Proliferative effects of chishao on injured peripheral neurons

The American Journal of Chinese Medicine
Wen-Kuei FangChih-Yang Huang

Abstract

The aim of the study was to evaluate the proliferative effects of chishao on neuron regeneration. A silicone rubber nerve guide across a 15-mm gap was filled with different concentrations of chishao (0-125 mg/ml) in the dissected sciatic nerve of the right leg in SD rats. The left legs were used as control. After eight weeks, the regenerated nerves showed dose-dependently activated fibroblast growth factor-2 (FGF-2) signaling with increased urokinase plasminogen activator (uPA), decreased plasminogen activator inhibitor-1 (PAI-1) and enhanced proliferative proteins, extracellular signal regulated kinase (ERK)- and c-Jun N-terminal kinase (JNK)-signalings. The results imply that applying an appropriate dose of chishao would be a potential approach for enhancing neuron regeneration.

References

Jan 2, 1990·Molecular and Cellular Endocrinology·P A AndreasenS N Stacey
Apr 1, 1990·The Journal of Cell Biology·J B Davis, P Stroobant
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·F BesnardG Labourdette
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K UnsickerM Sensenbrenner
Sep 1, 1994·Biological & Pharmaceutical Bulletin·M TomodaK Hirabayashi
Mar 1, 1993·Immunology Today·J J Cohen
Apr 4, 1997·Science·G K Michalopoulos, M C DeFrances
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·P A AndreasenM J Duffy
Oct 30, 2001·Anatomy and Embryology·C Grothe, G Nikkhah
Dec 21, 2002·The Journal of Biological Chemistry·James WitowskyBruce D Cuevas
May 30, 2003·The Annals of Pharmacotherapy·Anna L N Wong, Thomas Y K Chan
Oct 31, 2003·Biomaterials·Yueh-Sheng ChenChun-Hsu Yao
May 16, 2006·Apoptosis : an International Journal on Programmed Cell Death·Wei-Wen KuoChih-Yang Huang
May 15, 2007·Oncogene·D N DhanasekaranE P Reddy
Jun 9, 2007·Biochimica Et Biophysica Acta·Deborah T LeichtGuri Tzivion

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Citations

Jul 31, 2013·The American Journal of Chinese Medicine·Sheng-Chi LeeMing-Chang Wu
Nov 7, 2016·BMC Complementary and Alternative Medicine·Fanny Chui-Fun IpNancy Yuk-Yu Ip

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