Proliferative glomerulonephritis in lupus patients with human immunodeficiency virus infection: a difficult clinical challenge

Seminars in Arthritis and Rheumatism
Simona GindeaChaim Putterman

Abstract

To describe the unusual occurrence of systemic lupus erythematosus (SLE) with nephritis in human immunodeficiency virus (HIV)-infected individuals. Chart review-based report of a case of SLE with diffuse proliferative glomerulonephritis (DPGN) in an HIV-infected man, together with a literature review of previously published cases. We searched the English language medical literature from 1987 to 2009 using the following PubMed and Medline terms: "SLE," "HIV," "DPGN." In addition, we researched the role of mycophenolate mofetil (MMF) in the treatment of patients with HIV by using the keywords "MMF" and "HIV". An 18-year-old male patient with vertically transmitted HIV-1 infection presented with malaise, weight loss, malar rash, arthritis, proteinuria, and hematuria. Kidney biopsy confirmed the diagnosis of lupus nephritis (Class IV). He was treated successfully with high-dose corticosteroids and MMF, which were added to his baseline treatment of highly active antiretroviral therapy. The review of the literature identified a total of 18 cases of SLE appearing in HIV+ individuals, of which 11 patients had lupus nephritis. Among the latter, there were only 5 cases of proliferative (focal or diffuse) glomerulonephritis, and their tre...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·B DiamondM D Scharff
Jan 1, 1990·American Journal of Nephrology·V D'Agati, R Seigle
Sep 7, 1989·The New England Journal of Medicine·J StraussV Pardo
Jan 1, 1987·Annals of Internal Medicine·R WinchesterG Solomon
Jun 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A MaradonaV Asensi
May 1, 1995·Journal of the American Academy of Dermatology·I LuM E Grossman
Jun 1, 1994·Lupus·K ItohS Mori
Aug 1, 1993·Seminars in Arthritis and Rheumatism·H R Barthel, D J Wallace
Apr 29, 1993·The New England Journal of Medicine·R JindalL Burrows
May 1, 1993·The Journal of Experimental Medicine·C MohanS K Datta
Aug 1, 1996·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·G ContrerasJ J Bourgoignie
Jun 1, 1997·Arthritis and Rheumatism·R A Fox, D A Isenberg
Mar 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·B G ChangV D D'Agati
Oct 27, 1999·Rheumatology·P R SmithC J Skinner
Mar 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·V MialouP Cochat
May 3, 2001·The Pediatric Infectious Disease Journal·K O'KeefeR Johann-Liang
Feb 2, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Xiaobo WangAnne Davidson
Jun 14, 2003·International Journal of STD & AIDS·Leonardo CalzaFrancesco Chiodo
Jul 5, 2003·Blood·Anne-Geneviève MarcelinNicolas Dupin
Jan 30, 2004·Journal of the American Society of Nephrology : JASN·Jan J WeeningMichio Nagata
Mar 1, 2005·Lupus·E M Ginzler, C Aranow
Aug 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·François BouéDominique Costagliola
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Wonder Puryear DrakeNancy J Olsen
Dec 15, 2007·Annals of the Rheumatic Diseases·E J CepedaJ D Reveille
Apr 24, 2008·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Juan Jakez-OcampoLuis Llorente
Jun 26, 2008·Nature Clinical Practice. Rheumatology·Rashmi M MagantiFrances M Williams
Apr 3, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Clare L RossBarry Peters
May 5, 2009·Current Opinion in Rheumatology·Nigil Haroon, Robert D Inman
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Nirupa PatelLuis R Espinoza

❮ Previous
Next ❯

Citations

Mar 1, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Murli U PurswaniUNKNOWN IMPAACT 219/219C Study Team
Sep 13, 2015·Best Practice & Research. Clinical Rheumatology·Christine Fox, Karen Walker-Bone
Sep 24, 2014·Seminars in Arthritis and Rheumatism·Lawrence O Okong'oChristian Scott
Jun 11, 2014·Seminars in Arthritis and Rheumatism·Girish M ModyThozama Dubula
May 21, 2013·Clinical Journal of the American Society of Nephrology : CJASN·Matthew C FoyMohamed G Atta
Dec 26, 2016·Rheumatology·Karen Walker-BoneDuncan Churchill
Jan 19, 2019·Advances in Rheumatology·Vanessa HaxOdirlei Andre Monticielo
Mar 7, 2021·Viruses·Marco QuagliaVincenzo Cantaluppi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.