Proliferative lesions and metalloproteinase activity in murine lupus nephritis mediated by type I interferons and macrophages.

Proceedings of the National Academy of Sciences of the United States of America
Antigoni TriantafyllopoulouLionel B Ivashkiv

Abstract

Glomerulonephritis is a major cause of morbidity in patients with systemic lupus erythematosus. Although substantial progress has been made in the identification of pathogenic triggers that result in autoantibody production, little is known about the pathogenesis of aggressive proliferative processes that lead directly to irreversible glomerular damage and compromise of renal function. In this study, we describe a model of polyinosinic: polycytidylic acid-accelerated lupus nephritis in NZB/W mice that is characterized by severe glomerular proliferative lesions with de novo crescent formation, findings that are linked with decreased survival and adverse outcomes in lupus. Proliferative glomerulonephritis was associated with infiltrating kidney macrophages and renal expression of IFN-inducible genes, matrix metalloproteinases (MMPs), and growth factors. Crescent formation and renal MMP and growth factor expression were dependent on renal macrophages that expressed Il10, MMPs, osteopontin, and growth factors, including Pdgfc and Hbegf. Infiltrating macrophages and renal MMP expression were induced by type I IFN. These findings reveal a role for type I IFNs and alternatively activated macrophages in aggressive proliferative lesions...Continue Reading

References

Nov 1, 1978·The Journal of Experimental Medicine·B S AndrewsF J Dixon
Sep 14, 1994·Journal of Immunological Methods·N Van Rooijen, A Sanders
Mar 26, 1998·Journal of the American Society of Nephrology : JASN·K Steinmann-NiggliH P Marti
Jan 5, 2000·Kidney International·K L HudkinsC E Alpers
Jul 10, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Maki UrushiharaYasuhiro Kuroda
Jan 4, 2003·Nature Reviews. Immunology·Siamon Gordon
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emily C BaechlerTimothy W Behrens
Mar 19, 2003·The Journal of Experimental Medicine·Marie-Laure Santiago-RaberArgyrios N Theofilopoulos
Aug 3, 2004·Nature Reviews. Immunology·William C ParksYolanda S López-Boado
Feb 25, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexis MathianSophie Koutouzov
Aug 10, 2006·Current Opinion in Rheumatology·Anne Davidson, Cynthia Aranow
Nov 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy BergtoldRaphael Clynes
May 5, 2007·Nature Medicine·Roberto BaccalaArgyrios N Theofilopoulos
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
Jun 27, 2007·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Shuhei YoshimotoYoshihiko Saito
Oct 12, 2007·Kidney International·L Adalid-PeraltaS Koutouzov
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lena SchifferAnne Davidson
Apr 22, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu LiuHeather M Wilson
May 29, 2008·European Journal of Immunology·Anna-Marie FairhurstEdward K Wakeland
Jul 4, 2008·Kidney International·Anders A TveitaSvetlana N Zykova
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Dec 19, 2008·Arthritis Research & Therapy·Anders TveitaSvetlana N Zykova
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mariola Kurowska-StolarskaFoo Y Liew
Oct 30, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna-Marie FairhurstChandra Mohan

❮ Previous
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Citations

May 21, 2011·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tammo OstendorfJürgen Floege
Mar 27, 2012·International Urology and Nephrology·Sabine Brandt, Peter R Mertens
Sep 15, 2010·The Journal of Experimental Medicine·Giorgio Trinchieri
Oct 28, 2011·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Argyrios N TheofilopoulosRoberto Baccala
Apr 3, 2012·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Martin FlamantPierre-Louis Tharaux
Jul 20, 2012·Current Opinion in Rheumatology·Onkar P Kulkarni, Hans-Joachim Anders
Dec 14, 2011·Journal of Biomedicine & Biotechnology·Theophanis P KarageorgasClio P Mavragani
Nov 7, 2013·BMC Pediatrics·Devendra ShresthaHenish Shakya
Apr 6, 2013·BMC Medicine·Kenneth Michael Pollard, Dwight H Kono
Apr 16, 2010·Arthritis Research & Therapy·George D Kalliolias, Lionel B Ivashkiv
Oct 13, 2011·Arthritis Research & Therapy·Simanta Pathak, Chandra Mohan
Dec 24, 2011·Arthritis Research & Therapy·Tamara K Nowling, Gary S Gilkeson
Jan 25, 2013·Arthritis Research & Therapy·Ornella J RulloBetty P Tsao
Jun 12, 2013·Molecular Medicine·Natalya SeredkinaOle Petter Rekvig
Jan 10, 2014·Seminars in Immunopathology·Hans-Joachim Anders, Agnes B Fogo
Aug 28, 2015·Kidney International Supplements·Tammo OstendorfJürgen Floege
Jul 20, 2010·Journal of Autoimmunity·Elena Kontaki, Dimitrios T Boumpas
Nov 12, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kritika Ramani, Partha S Biswas
Aug 26, 2015·Journal of Autoimmunity·Kaitlyn L ClarkJ Michelle Kahlenberg
Oct 7, 2015·Cytokine·Kritika Ramani, Partha S Biswas
Oct 19, 2010·Arthritis and Rheumatism·Zheng LiuAnne Davidson
May 29, 2014·Arthritis & Rheumatology·Ranjit SahuAnne Davidson
Apr 1, 2015·Nature Reviews. Nephrology·Chandra Mohan, Chaim Putterman
Sep 24, 2013·JAK-STAT·Isabella RauchThomas Decker
Apr 10, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Kyriakos A Kirou, Elena Gkrouzman
Jun 3, 2016·Frontiers in Immunology·Yasuaki TamuraKaori Sawada
Nov 2, 2016·The Journal of Clinical Investigation·Michel J MassaadRaif S Geha
Mar 16, 2017·European Journal of Immunology·Michael MurphyAndrei E Medvedev
Jan 26, 2018·The Journal of Clinical Investigation·Xiaoping QingJane E Salmon
Jan 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ailing LuGuangxun Meng
Oct 1, 2014·Nature Reviews. Nephrology·Natasha M RogersJeremy Hughes
Feb 20, 2018·Immunology·Samanta C FunesAlexis M Kalergis
Aug 10, 2013·Journal of the American Society of Nephrology : JASN·Maciej Lech, Hans-Joachim Anders

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