PMID: 9631633Jun 19, 1998Paper

Proliferative potential and apoptosis in rat glioma cell lines after hyperthermia

Neurologia Medico-chirurgica
R Y LiuT Ohmoto

Abstract

The proliferative potential of cultured rat glioma cells (C6 and 9L) was evaluated after hyperthermia using immunohistochemical staining with bromodeoxyuridine (BrdU) and Ki-67 monoclonal antibodies. Apoptosis was assessed by in situ end-labeling of deoxyribonucleic acid breaks. Both BrdU and Ki-67 labeling indexes decreased with increasing hyperthermia time. The decrease of the Ki-67 labeling index was not as great as that of the BrdU labeling index. The number of apoptotic cells increased with time after hyperthermia. These results indicate that the antitumor effect of hyperthermia may reflect the induction of apoptosis in the cells within the cell cycle, and the resultant reduction of the proliferative potential of surviving cells, especially in the S phase.

Citations

Apr 11, 2001·Ultrasound in Medicine & Biology·N VykhodtsevaK Hynynen
Jan 26, 2006·Neurologia Medico-chirurgica·Takeo UzukaRyuichi Tanaka
Jul 16, 2002·Neurological Research·Kenji WatanabeTakashi Watanabe

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
E M SchopmanG W Barendsen
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
J AsaumiY Hiraki
International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
M UrakawaT Matsuda
© 2022 Meta ULC. All rights reserved