Proline-Based Cyclic Dipeptides from Korean Fermented Vegetable Kimchi and from Leuconostoc mesenteroides LBP-K06 Have Activities against Multidrug-Resistant Bacteria

Frontiers in Microbiology
Rui LiuSa-Ouk Kang

Abstract

Lactobacillus plantarum and Leuconostoc mesenteroides play a prominent role as functional starters and predominant isolates in the production of various types of antimicrobial compound-containing fermented foods, especially including kimchi. In the case of the bioactive cyclic dipeptides, their racemic diastereomers inhibitory to bacteria and fungi have been suggested to come solely from Lactobacillus spp. of these strains. We previously demonstrated the antifungal and antiviral activities of proline-based cyclic dipeptides, which were fractionated from culture filtrates of Lb. plantarum LBP-K10 originated from kimchi. However, cyclic dipeptides have not been identified in the filtrates, either from cultures or fermented subject matter, driven by Ln. mesenteroides, which have been widely used as starter cultures for kimchi fermentation. Most importantly, the experimental verification of cyclic dipeptide-content changes during kimchi fermentation have also not been elucidated. Herein, the antibacterial fractions, including cyclo(Leu-Pro) and cyclo(Phe-Pro), from Ln. mesenteroides LBP-K06 culture filtrates, which exhibited a typical chromatographic retention behavior (tR), were identified by using semi-preparative high-performanc...Continue Reading

References

Jan 1, 1990·Progress in Drug Research. Fortschritte Der Arzneimittelforschung. Progrès Des Recherches Pharmaceutiques·D T Witiak, Y Wei
Jan 1, 1995·Peptides·C Prasad
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·H S Cheigh, K Y Park
Feb 24, 1999·Critical Reviews in Food Science and Nutrition·A S NaiduR A Clemens
Apr 13, 1999·Journal of Applied Microbiology·M L Niku-PaavolaA Haikara
Sep 30, 2000·Applied and Environmental Microbiology·M G GänzleW P Hammes
Dec 1, 2000·The Journal of Antibiotics·O S KwonC J Kim
Feb 13, 2001·Letters in Applied Microbiology·C FoucaudM Desmazeaud
Feb 15, 2002·International Journal of Food Microbiology·Winy Messens, Vuyst Luc De
Oct 18, 2002·International Journal of Food Microbiology·R Paul RossC Hill
Feb 21, 2003·FEMS Microbiology Letters·Jesper MagnussonJohan Schnürer
Nov 25, 2003·Biology of the Cell·Miguel FreitasGermain Trugnan
Jan 1, 1997·Applied and Environmental Microbiology·C FoucaudJ Richard
Aug 9, 2006·Critical Reviews in Microbiology·María Fernández, Manuel Zúñiga
Apr 26, 2007·FEMS Microbiology Letters·Helena LindAnders Broberg
Oct 10, 2007·Journal of Applied Microbiology·S D TodorovL M T Dicks
Aug 30, 2008·Journal of Food Protection·Susan Rouse, Douwe van Sinderen
Nov 1, 2008·The Journal of Microbiology·Dongyun LeeJeongho Kim
Nov 26, 2009·ACS Chemical Biology·Jennifer CampbellHelen E Blackwell
Mar 17, 2010·International Journal of Food Microbiology·E J Yang, H C Chang
Dec 17, 2010·Chemistry & Biodiversity·Riming HuangYonghong Liu
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jingru LiJohn K McCormick
Feb 15, 2011·Applied and Environmental Microbiology·Ji Young JungChe Ok Jeon
Dec 23, 2011·International Journal of Food Microbiology·Ji Young JungChe Ok Jeon
May 15, 2012·Current Microbiology·Hongjuan LiJiaping Lv
Apr 17, 2013·International Journal of Food Microbiology·Sang Hyeon JeongChe Ok Jeon
Apr 18, 2013·FEMS Microbiology Letters·Saima NazJean-Paul Vernoux
Jan 5, 2014·The Journal of Microbiology·Min-Kyu KwakSa-Ouk Kang
Jan 7, 2014·The Journal of Microbiology·Min-Kyu KwakSa-Ouk Kang
Jan 15, 2014·Applied Microbiology and Biotechnology·Ji Young JungChe Ok Jeon
Sep 14, 2014·Trends in Molecular Medicine·Ilaria BellezzaAlba Minelli

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Citations

Jan 19, 2018·Scientific Reports·Jianxi YingYufen Zhao
Oct 9, 2019·Advanced Pharmaceutical Bulletin·Fataneh Hashempour-BaltorkMatin Alizadeh
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Phui-Chyng YapHai Yen Lee

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BETA
glycosylation

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ChemStation HPLC
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