Proline-catalyzed direct inverse electron demand diels-alder reactions of ketones with 1,2,4,5-tetrazines

Organic Letters
Hexin XieWei Wang

Abstract

An organocatalytic direct inverse electron demand Diels-Alder reaction of ketones with 1,2,4,5-tetrazines has been developed. The process is efficiently catalyzed by proline to give Diels-Alder adducts pyridazines in high yields.

References

Aug 30, 2001·Journal of the American Chemical Society·D L Boger, J Hong
Jun 26, 1996·The Journal of Organic Chemistry·András KotschyAndrás Messmer
Oct 24, 2001·The Journal of Organic Chemistry·Dale L. BogerRobert M. Garbaccio
Apr 17, 2003·Angewandte Chemie·Karsten Juhl, Karl Anker Jørgensen
Apr 26, 2003·The Journal of Organic Chemistry·Danielle R SoenenDale L Boger
Sep 30, 2004·Angewandte Chemie·Peter I Dalko, Lionel Moisan
May 20, 2005·Angewandte Chemie·Matthew D HelmJoseph P A Harrity
Oct 8, 2005·The Journal of Organic Chemistry·Yat Fan SuenMark J Kurth
Jun 17, 2006·The Journal of Organic Chemistry·Richard HoogenboomUlrich S Schubert
Nov 30, 2006·Angewandte Chemie·Claudio Palomo, Antonia Mielgo
Aug 23, 2007·Organic Letters·Alessandro VolonterioJulius Rebek
Dec 13, 2007·Chemical Reviews·Santanu MukherjeeBenjamin List

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Citations

Jan 26, 2013·Chemical Reviews·Bagher Eftekhari-SisAli Akbari
Jul 10, 2014·Dalton Transactions : an International Journal of Inorganic Chemistry·Samantha E Bodman, Christopher M Fitchett
May 13, 2017·Chemistry, an Asian Journal·Zhuang Mao PngJianwei Xu
Oct 11, 2011·Chemistry : a European Journal·Mokhtaria BelkheiraCyril Bressy
Jun 5, 2012·Chemical Communications : Chem Comm·Polyssena Renzi, Marco Bella
Oct 20, 2012·Chemical Society Reviews·Radleigh A A Foster, Michael C Willis
Feb 6, 2010·Organic & Biomolecular Chemistry·Zhao-Quan HeYing-Chun Chen
Mar 19, 2014·Chemical Communications : Chem Comm·Yongming DengHong Wang
Mar 27, 2020·Chemical Communications : Chem Comm·Huan XiongHongtao Xu
Dec 17, 2008·Organic Letters·Orazio A AttanasiStefania Santeusanio
Jan 6, 2021·Chemical Reviews·Titas DebRaphael M Franzini
Oct 27, 2009·Journal of Combinatorial Chemistry·Chih-Hau ChenChung-Ming Sun
Sep 6, 2019·Organic Letters·Jannick Meinecke, Ulrich Koert

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