Proline protects liver from D-galactosamine hepatitis by activating the IL-6/STAT3 survival signaling pathway

Amino Acids
Yoko ObayashiMichio Takahashi

Abstract

The oral administration of proline, one of the non-essential amino acids, has been shown to effectively protect the liver from D-galactosamine (GalN)-induced liver injury and to improve the survival rate. The aim of this study was to investigate the mechanism of this protective action of proline. We paid particular attention to the effect of proline on inflammatory activation, regenerative response, and the associated signal transduction in the liver. Male Fischer rats received intraperitoneal injections of GalN (1.4 g/kg) with or without the oral administration of proline (2 g/kg) 1 h before GalN treatment. Liver pathology, plasma indices of inflammation, and the level of proliferative marker in the liver were monitored. The hepatic activation of interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)-3 pathway, which is downstream of tumor necrosis factor (TNF)-α/nuclear factor-κB, was also studied. GalN induced massive inflammatory expansion in the liver, leading to a high death rate (60 %) more than 72 h after the treatment. Proline administration significantly suppressed inflammatory infiltration in the live after 48 h, which was accompanied by depletion of plasma TNF-α, glutamic oxaloacetic transamina...Continue Reading

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Citations

Sep 13, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Reza HeidariNarges Abdoli
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Ji RyuSang-Jip Nam

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