Abstract
The oral administration of proline, one of the non-essential amino acids, has been shown to effectively protect the liver from D-galactosamine (GalN)-induced liver injury and to improve the survival rate. The aim of this study was to investigate the mechanism of this protective action of proline. We paid particular attention to the effect of proline on inflammatory activation, regenerative response, and the associated signal transduction in the liver. Male Fischer rats received intraperitoneal injections of GalN (1.4 g/kg) with or without the oral administration of proline (2 g/kg) 1 h before GalN treatment. Liver pathology, plasma indices of inflammation, and the level of proliferative marker in the liver were monitored. The hepatic activation of interleukin-6 (IL-6)/signal transducer and activator of transcription (STAT)-3 pathway, which is downstream of tumor necrosis factor (TNF)-α/nuclear factor-κB, was also studied. GalN induced massive inflammatory expansion in the liver, leading to a high death rate (60 %) more than 72 h after the treatment. Proline administration significantly suppressed inflammatory infiltration in the live after 48 h, which was accompanied by depletion of plasma TNF-α, glutamic oxaloacetic transamina...Continue Reading
References
Oct 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R P VemuruS Gupta
Jan 1, 1985·Current Topics in Cellular Regulation·J M Phang
Jan 1, 1980·Annual Review of Biochemistry·E Adams, L Frank
Aug 1, 1983·Archives of Biochemistry and Biophysics·C H Hagedorn, J M Phang
Nov 1, 1995·Pharmacology, Biochemistry, and Behavior·R L HawkinsK Torii
Nov 22, 1996·Science·D E CressmanR Taub
Oct 1, 1998·The American Journal of Physiology·Y XuM J Czaja
Feb 19, 1999·Immunity·K TakedaS Akira
Nov 5, 1999·Biological & Pharmaceutical Bulletin·Y ItokazuT Omata
Dec 29, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K KovalovichR Taub
May 4, 2001·The Journal of Biological Chemistry·J J SchuringaW Kruijer
May 12, 2001·The Journal of Biological Chemistry·K KovalovichR Taub
Jun 8, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W LiR Taub
Sep 5, 2001·Science· Chen LfW C Greene
Jan 12, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xavier AldeguerKim M Olthoff
May 29, 2002·The Journal of Biological Chemistry·Wei LiRebecca Taub
Dec 25, 2002·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Narci TeohGeoffrey Farrell
Oct 3, 2003·The Journal of Clinical Investigation·Rebecca Taub
May 26, 2006·Biochemical Pharmacology·Geoffrey GloireJacques Piette
Jun 6, 2006·Biotechnology and Bioengineering·Abhay SinghJuergen Hahn
Nov 7, 2006·Surgery·Tadashi MatsumotoDavid P Foley
Jul 31, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Akira MohXin-Yuan Fu
Apr 7, 2009·Cancer Cell·Heehyoung LeeHua Yu
Jul 8, 2010·Journal of Hepato-biliary-pancreatic Sciences·Masato Fujiyoshi, Michitaka Ozaki
Aug 11, 2010·Amino Acids·Guoyao WuThomas E Spencer
Citations
Dec 19, 2012·Amino Acids·Guoyao WuYulong Yin
Jan 16, 2016·Amino Acids·Yusheng LiGuanghua Lei
May 20, 2015·SpringerPlus·Yoko ObayashiMichio Takahashi
Mar 20, 2015·PloS One·Jing WangSiyan Zhan
Sep 13, 2018·Journal of Basic and Clinical Physiology and Pharmacology·Reza HeidariNarges Abdoli
Dec 30, 2017·Experimental and Therapeutic Medicine·Minglin ZhuJinping Zhao
Dec 19, 2020·Phytochemical Analysis : PCA·Wanning ChenLifeng Han
Jan 24, 2021·Molecular Biology Reports·Hongwei TangShuijun Zhang
Dec 17, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Min-Ji RyuSang-Jip Nam
Nov 9, 2021·Andrologia·Bahareh MoradiMozafar Khazaei