Prolongation of allograft survival in ccr7-deficient mice

Transplantation
Jan BeckmannMatthias Hoffmann

Abstract

Lymphocyte homing to secondary lymphoid organs is thought to be required for initiation of the alloreactive immune response. Because CCR7 is the essential chemokine receptor responsible for lymphocyte and dendritic cell homing to secondary lymphoid organs, allograft survival was analyzed in CCR7-deficient (CCR7) mice. Heterotopic heart and skin allotransplantation was performed in CCR7 and wild-type (WT) recipients. Graft survival was monitored daily. Grafts and draining lymph nodes were analyzed by immunohistology and flow cytometry at different time points. Groups of mice were splenectomized at the day of allotransplantation. A significant though modest prolongation of allograft survival in CCR7 recipients was observed for heart grafts (WT, 7.3 +/- 0.5 days; CCR7, 10.7 +/- 2.8 days) and skin grafts (WT, 8.9 +/- 0.9 days; CCR7, 12.3 +/- 0.9 days). This was accompanied by a delay in the cellular infiltration of allografts. T-cell accumulation and expansion in the draining lymph nodes in CCR7 recipients was severely impaired. Splenectomy had only a moderate prolongation effect on allograft survival in CCR7 mice. These results suggest that CCR7-dependent processes support allograft rejection yet are dispensable for the rejection ...Continue Reading

References

Nov 1, 1990·The Journal of Experimental Medicine·C P LarsenJ M Austyn
Jan 1, 1984·Immunological Reviews·N L AscherR L Simmons
Nov 21, 2000·The Journal of Experimental Medicine·W W HancockC Gerard
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·L A RobinsonT M Coffman
Oct 17, 2001·Transplantation·W GaoW W Hancock
Nov 2, 2001·Nature Medicine·R ChinY X Fu
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel KreiselBruce R Rosengard
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ping ZhouMaria-Luisa Alegre

❮ Previous
Next ❯

Citations

Apr 17, 2013·Cytokine & Growth Factor Reviews·Iain ComerfordShaun R McColl
Oct 19, 2005·The Journal of Experimental Medicine·Hongsi JiangYoshinori Fukui
Nov 28, 2007·Annual Review of Pathology·Lynn D CornellRobert B Colvin
Feb 1, 2007·Current Opinion in Organ Transplantation·Bridget L Colvin, Angus W Thomson
Dec 22, 2006·Expert Review of Anticancer Therapy·Simon J HarrisonH Miles Prince
Jun 16, 2012·Immunology Letters·Peter J Nelson, Mauro M Teixeira
Sep 29, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Minjie MaoSong Rong
Nov 26, 2008·Clinics in Laboratory Medicine·Bridget L ColvinAngus W Thomson
Aug 13, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Bridget L ColvinAngus W Thomson
Aug 11, 2006·Cell Transplantation·Shaheed MeraniA M James Shapiro
Sep 30, 2016·Annals of Medicine·Anna NeveFrancesco Paolo Cantatore
Aug 11, 2006·Journal of the American Society of Nephrology : JASN·Ekkehard ZieglerStefan Krautwald
Feb 5, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·A KoscielnyJ C Kalff
Apr 1, 2006·Cell Transplantation·Shaheed MeraniA M James Shapiro
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liqing WangWayne W Hancock
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ekkehard ZieglerStefan Krautwald
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kym R GarrodSang-Mo Kang
Feb 27, 2014·The Journal of Clinical Investigation·Alexander Sasha KrupnickDaniel Kreisel
Oct 4, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Richard T RobinsonAndrea M Cooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Bridget L ColvinAngus W Thomson
Journal of the American Society of Nephrology : JASN
Ekkehard ZieglerStefan Krautwald
© 2022 Meta ULC. All rights reserved