Prolongation of clozapine-induced leukopenia with olanzapine treatment

Progress in Neuro-psychopharmacology & Biological Psychiatry
Aslihan Sayin, Behçet Cosar

Abstract

Clozapine is a well-known antipsychotic to cause fatal agranulocytosis but there are only a few case reports about the risk of leukopenia and agranulocytosis associated with other atypical antipsychotics. Olanzapine has structural pharmacological similarities to those of clozapine and reports about haematological adverse effects of olanzapine include three groups: the first group includes cases of olanzapine-induced neutropenia, the second informing that olanzapine is safe after clozapine induced agranulocytosis and the third group forms prolongation of clozapine-induced leukopenia with olanzapine use. The aim of this paper is to report a case of prolongation of clozapine-induced leukopenia despite olanzapine treatment and discuss leukopenia caused by atypical antipsychotic use in the light of recent and limited literature.

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Citations

Mar 14, 2013·Journal of Child and Adolescent Psychopharmacology·Michelle Wilson, John Brett Offenberger
Apr 15, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Szu-Ying WuMing H Hsieh
Sep 19, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Emmanuel StipAdham Mancini-Marïe
Jun 15, 2010·Toxicology and Industrial Health·Hasan Türkez, Başak Toğar
Dec 28, 2006·CNS Drugs·Mona BoulesElliott Richelson
Apr 28, 2007·The Australian and New Zealand Journal of Psychiatry·Karuppiah Jagadheesan, Jean Mehrtens
Aug 14, 2008·The Annals of Pharmacotherapy·Steven C StonerJason T Lurk
Mar 7, 2018·Journal of Psychiatric Practice·Luke Sy-Cherng WoonLai Fong Chan
Dec 22, 2007·Human Psychopharmacology·Robert J Flanagan, Louisa Dunk

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