Prolongation of skin allograft survival in H-2 K and I region-incompatible mice by pretransplant blood transfusion

Transplantation
H OkazakiA P Monaco

Abstract

The effect of donor specific and nonspecific pretransplant blood transfusion on skin allograft survival was studied in a mouse model, using skin donor-recipient combinations that differed at the K and I regions of the H-2 complex. In the first series of experiments, B6AF1 mice were treated with antilymphocyte serum (ALS) and grafted with DBA/2 skin. This donor-recipient combination differs in the K and I regions of the H-2 complex. Recipients were transfused 10 days before grafting with donor-specific DBA/2 blood or blood from various donors which were either completely incompatible at the H-2 complex with DBA/2 or shared various H-2 specificities with DBA/2. Only donor-specific DBA/2 blood or blood from donors sharing the K and I regions of the H-2 with DBA/2 prolonged DBA/2 skin graft survival. Donor-specific blood was effective over a wide interval between transfusion and grafting (days -50 to -10). In a second series of experiments using congenic strains of mice, the effect of pretransplant transfusions was studied in the B10.D2 to B10.A combination. These strains differ at the K and I region of the H-2, but share the same minor histocompatibility antigens. ALS-treated B10.A recipients were transfused either with donor-spec...Continue Reading

Citations

Dec 26, 2001·Transplantation Proceedings·R O Garcia-MoralesJ Miller
Sep 24, 1998·Transplantation Proceedings·M A HardyJ Anastasatos
Sep 24, 1998·Transplantation Proceedings·C Suberbielle-BoisselC Raffoux
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Himeno, R A Good
Apr 1, 1993·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y NakafusaM W Flye
Dec 1, 1985·British Journal of Haematology·D P SingalM A Blajchman

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