Prolongation of skin allograft survival in rats by the transplantation of microencapsulated xenogeneic neonatal porcine Sertoli cells

Biomaterials
Giovanni BistoniR Calafiore

Abstract

Skin rejection remains a major hurdle in skin reconstructive transplantation surgery. In fact, 85% of the grafted patients experience at least one episode of acute skin rejection in the first year. It has been observed that Sertoli cells (SC), when co-transplanted with allo- or xenogeneic cell/tissues, can induce graft acceptance in the absence of systemic immunosuppression. A method aimed at significantly prolonging skin allografts in rats transplanted with barium alginate-based microencapsulated xenogeneic porcine SC (SC-MCs) is described. Results demonstrated that intraperitoneal (IP) transplantation of SC-MCs with high cellular viability and function can significantly prolong allogeneic skin grafts when compared to transplantation controls receiving only empty alginate capsules (E-MCs). Lymphocytic infiltration at the skin graft site was not observed in 80% of the SC-MCs transplanted rats and these recipient animals showed a significant increased expression of T regulatory (Tregs) cells when compared to E-MCs transplantation controls. The findings of this report further substantiate the positive therapeutic effects of SC on transplantation technology mediated by Sertoli cell-induced alterations of the host's immune system a...Continue Reading

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Citations

Oct 22, 2013·Journal of Reproductive Immunology·Robert De RoseWendy R Winnall
Sep 12, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giovanni LucaRiccardo Calafiore
May 7, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Edorta SantosGorka Orive
Mar 27, 2019·Cell Proliferation·Sara ChiappalupiGuglielmo Sorci
Aug 4, 2020·Molecular Reproduction and Development·Helena D Zomer, Prabhakara P Reddi
Jan 22, 2015·Journal of Leukocyte Biology·Wendy R WinnallStephen J Kent
Dec 3, 2016·Essays in Biochemistry·Lucas B NavesSeeram Ramakrishna
Jun 26, 2020·Frontiers in Immunology·Helong DaiNatasha M Rogers
Apr 30, 2021·Seminars in Cell & Developmental Biology·Rachel L WashburnJannette M Dufour

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