Prolongation of the follicular phase in in vitro fertilization results in a lower ongoing pregnancy rate in cycles stimulated with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonists

Fertility and Sterility
E M KolibianakisP Devroey

Abstract

To assess the effect of altering the timing of hCG administration on ongoing pregnancy rates in patients stimulated with recombinant FSH (rec-FSH) and GnRH antagonists for IVF. Prospective, randomized, controlled trial. Tertiary referral center. Four hundred thirteen patients undergoing IVF. Rec-FSH stimulation starting on day 2 of the cycle combined with daily GnRH antagonist starting on day 6 of stimulation. Patients were randomized to receive 10000 IU of hCG either as soon as at least three follicles were >or=17 mm on ultrasound (early-hCG group, 208 patients) or 2 days later after this criterion was met (late-hCG group, 205 patients). Ongoing pregnancy rate. Fertilization rates and number and quality of embryos transferred did not differ between the two groups. However, a significantly lower ongoing pregnancy rate was present in the late-hCG as compared with the early-hCG group (25.0% vs. 35.6%, respectively). Prolongation of the follicular phase in patients stimulated with rec-FSH and GnRH antagonists for IVF does not affect oocyte or embryo quality but is associated with a significantly lower ongoing pregnancy rate.

References

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Citations

Oct 1, 2013·Reproductive Biology and Endocrinology : RB&E·Erik E HauzmanJuan A Garcia-Velasco
Apr 25, 2014·Reproductive Biology and Endocrinology : RB&E·Frank VandekerckhovePetra De Sutter
Sep 18, 2014·Journal of Assisted Reproduction and Genetics·Yi LiDong-Zi Yang
Jan 3, 2016·Human Reproduction·Christophe BlockeelHerman Tournaye
Jun 12, 2013·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumSlavko Oreškovic
Apr 16, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Ying ChenHongbo Qi
Dec 1, 2006·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Stefano PalombaFulvio Zullo
May 21, 2014·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Miro KasumLidija Beketić-Orešković
May 20, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Kiper AslanBaris Ata
Jun 1, 2005·Reproductive Biomedicine Online·William Ledger
Jun 1, 2005·Reproductive Biomedicine Online·Ricardo Enrique FelberbaumKlaus Diedrich
Mar 2, 2012·Reproductive Biomedicine Online·M Al-AzemiH M Fatemi
Jun 23, 2005·Reproductive Biomedicine Online·Efstratios M KolibianakisPaul Devroey
Sep 4, 2008·Reproductive Biomedicine Online·H M FatemiP Devroey
Apr 27, 2010·Fertility and Sterility·Peter HumaidanEvangelos G Papanikolaou
Oct 10, 2007·Fertility and Sterility·Jolanda C BoxmeerRégine P M Steegers-Theunissen
Nov 10, 2004·Fertility and Sterility·Efstratios KolibianakisPaul Devroey
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Jul 21, 2010·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Turgut VarLeyla Mollamahmutoglu
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Jun 13, 2018·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Barbara LawrenzHuman Fatemi
Jul 10, 2018·Endocrine Reviews·Ali AbbaraWaljit S Dhillo

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