PMID: 9180596May 1, 1997Paper

Prolongation of the QTc interval in African children treated for falciparum malaria

The American Journal of Tropical Medicine and Hygiene
L vn SeidleinB Greenwood

Abstract

Antimalarial drugs can affect the heart and trigger life-threatening arrhythmias. However, little is known about the frequency with which cardiac abnormalities occur during uncomplicated attacks of malaria. Therefore, we have studied the electrocardiograms of 139 Gambian children with uncomplicated falciparum malaria who were treated with co-artemether, pyrimethamine/sulfadoxine, or chloriquine. The QTc intervals were measured on presentation, and four and eight days after treatment. No significant differences in mean QTc or heart rate were found between children in the three treatment groups on days 0, 4, or 8. After adjustment for the type of antimalarial thearapy in an analysis of variance, the mean (SD) QTc intervals on days 0, 4, and 8 were 402 (22.6), 416 (23.1), and 405 (24.3) msec, respectively. The mean QTc on day 4 was significantly longer than the mean QTc on days 0 or 8 (P < 0.01 in both cases). A quadratic line was fitted for QTc against time for each antimalarial therapy. No significant differences were found between the quadratic lines of the three groups. A weak association was found between QTc and the degree of parasitemia (r = 0.17, P = 0.04) and temperature (r = -0.23, P = 0.01) measured on day 0. The QTcs w...Continue Reading

Citations

Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Pierangelo Chinello, Nicola Petrosillo
Dec 25, 2012·BMC Cardiovascular Disorders·Alessandra FiorentiniPierangelo Chinello
Sep 27, 2018·Antimicrobial Agents and Chemotherapy·Pere Millat-MartínezOriol Mitjà
Dec 16, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SowunmiL A Salako
Sep 24, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·A SowunmiA M Oduola
Oct 16, 2004·Expert Review of Anti-infective Therapy·Walther H Wernsdorfer
Dec 23, 1998·British Journal of Clinical Pharmacology·B K ParkM Pirmohamed
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·F EzzetN J White
Dec 14, 2006·Expert Opinion on Pharmacotherapy·Gilbert KokwaroAlexis Nzila

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